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a, b, Structure of MapSPARTA in apo state (pink) overlaid with MapSPARTA state I (blue, a) and state II (green, b). The TIR domain is enlarged.
c, d, Charge and shape complementarity between asymmetric TIRs (c) and electrostatic repulsion between symmetric TIRs (d).
e, Schematic diagram illustrating the assembly of MapSPARTA tetramer upon RNA/DNA binding.
