Table 1.
Study Outcomes Across Cohort A, Cohort B, and Combined Study Cohort
| Outcomes | Cohort A (GM) | Cohort B (UK) | Combined Study Cohort | |
|---|---|---|---|---|
| Upstaging clinical ssN2 to pathologic msN2 | 19/56 (34) | 19/59 (32) | 38/115 (33) | |
| Clinical staging (radiology—CT and PET) | Normal mediastinum | 9/56 (16) | 2/59 (3) | 11/115 (10) |
| Single radiologically abnormal LN | 47/56 (84) | 54/59 (92) | 101/115 (88) | |
| Multiple radiologically abnormal LNs | 0/56 (0) | 3/59 (5) | 3/115 (2) | |
| Reason for upstaging (missed N2 nodes by staging EBUS) | Inaccessible LN during EBUS5,6,8,9 | 9/19 (47) | 4/19 (21) | 13/38 (34) |
| False-negative EBUS sampling | 6/19 (32) | 4/19 (21) | 10/38 (26) | |
| Accessible LN but not sampled during EBUS | 4/19 (21) | 11/19 (58) | 15/38 (40) | |
| The radiological appearance of missed N2 nodes | Radiologically normal | 19/19 (100) | 18/19 (95) | 37/38 (97) |
| Radiologically abnormal | 0/19 (0) | 1/19 (5) | 1/38 (3) | |
Note: All values are given in n/N (%).
CT, computed tomography; EBUS, endobronchial ultrasound; GM, Greater Manchester; LN, lymph node; msN2, multistation N2; PET, positron emission tomography; ssN2, single-station N2; UK, United Kingdom.