| Khodarahmi et al. [13] (2022) |
The Role of Dietary Glycemic Index and Glycemic Load in Mediating Genetic Susceptibility via MC4R s17782313 Genotypes to Affect Cardiometabolic Risk Factors among Apparently Healthy Obese Individuals |
Cross-sectional |
rs17782313 (CC) |
287 males and females, healthy |
20–50 ≥ 30 kg/m2
|
Negative |
↓Basal metabolic rate and high-density lipoprotein cholesterol |
| ↑Low-density lipoprotein cholesterol |
| Alizadeh et al. [14] (2022) |
Interaction of MC4R rs17782313 Variants and Dietary Carbohydrate Quantity and Quality on Basal Metabolic Rate and General and Central Obesity in Overweight/Obese Women: A Cross-Sectional Study |
Cross-sectional |
rs17782313 (CC & TC) |
282 females, healthy |
18–56 ≥ 25 kg/m2
|
Negative |
↑Waist circumference and body mass index |
| Adamska-Patruno et al. [15] (2021) |
An Association Between Diet and MC4R Genetic Polymorphism, in Relation to Obesity and Metabolic Parameters-A Cross Sectional Population-Based Study |
Cross-sectional |
rs17782313 (CC) |
1,549, males and females, type 2 diabetes |
18–79 > 25 kg/m2
|
Negative |
↓Subcutaneous fat content (SAT) |
| ↑Body mass index, body fat content, visceral fat content (VAT), and VAT/SAT ratios |
| Mohammadi et al. [16] (2020) |
The Interaction Between Dietary Non-Enzymatic Antioxidant Capacity (NEAC) With Variants of Melanocortin-4 Receptor (MC4R) 18q21.23-rs17782313 Locus on Hypothalamic Hormones and Cardio-Metabolic Risk Factors in Obese Individuals From Iran |
Cross-sectional |
rs17782313 (CC) |
287 males and females, healthy |
20–50 ≥ 30 kg/m2
|
Positive & negative |
↓High-density lipoprotein cholesterol, quantitative insulin sensitivity check index, insulin, serum glucose, α-melanocyte stimulating hormone, and triglyceride |
| ElhamKia et al. [17] (2022) |
The Interaction Between Dietary Total Antioxidant Capacity and MC4R Gene and HOMA-IR in Metabolically Healthy and Unhealthy Overweight and Obese Women |
Cross-sectional |
rs17782313 (CC & TC) |
237 females, healthy |
18–50, 25–40 kg/m2
|
Not significant |
No significant associations were found with lipid profile and metabolic parameters. |
| Khodarahmi et al. [18] (2020) |
Dietary Quality Indices Modifies the Effects of Melanocortin-4 Receptor (MC4R) rs17782313 Polymorphism on Cardiometabolic Risk Factors and Hypothalamic Hormones in Obese Adults |
Cross-sectional |
rs17782313 (CC & TC) |
188 males and females, healthy |
20–50 ≥ 30 kg/m2
|
Positive |
↓Low-density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure, and serum glucose levels |
| Zarei et al. [19] (2022) |
The Interaction Between Alternative Healthy Eating Index and MC4R rs17782313 Gene Variants on Central and General Obesity Indices in Women: A Cross‐Sectional Study |
Cross-sectional |
rs17782313 (CC) |
291 females, healthy |
18–48 ≥ 25 kg/m2
|
Positive |
↓Visceral fat area, fat mass, body mass index, and hip circumference |
| Khodarahmi et al. [20] (2020) |
Melanocortin-4 Receptor (MC4R) rs17782313 Polymorphism Interacts With Dietary Approach to Stop Hypertension (DASH) and Mediterranean Dietary Score (MDS) to Affect Hypothalamic Hormones and Cardio-Metabolic risk Factors Among Obese Individuals |
Cross-sectional |
rs17782313 (CC) |
288 males and females, healthy |
20–50 ≥ 30 kg/m2
|
Positive |
↓Systolic blood pressure, atherogenic index of plasma, serum glucose, and triglyceride levels |
| Ortega-Azorín et al. [21] (2012) |
Associations of the FTO rs9939609 and the MC4R rs17782313 Polymorphisms With Type 2 Diabetes Are Modulated by Diet, Being Higher When Adherence to the Mediterranean Diet Pattern Is Low |
Case-control |
rs17782313 (CC) |
7,052, male and female mean BMI 29.9 kg/m2
|
Mean age 70, type 2 diabetes |
Positive |
The MC4R rs17782313 interacted with the Mediterranean diet in its relation to type 2 diabetes. |
| Koochakpoor et al. [22] (2016) |
Effect of Interactions of Polymorphisms in the Melanocortin‐4 Receptor Gene With Dietary Factors on the Risk of Obesity and Type 2 Diabetes |
Systematic review |
rs17782313 (CC) |
Not clear, male and female |
Not clear, type 2 diabetes |
Positive |
Mediterranean diet interacted with MC4R rs17782313 on the risk of type 2 diabetes. |
| Rasaei et al. [23] (2023) |
Investigation the Interaction of Dietary Fat Quality Indices and the MC4R Gene in Metabolically Healthy and Unhealthy Overweight and Obese Women |
Cross-sectional |
rs17782313 (CC) |
279 females, healthy |
18–68, 25–40 kg/m2
|
Negative |
↑Homeostatic model assessment for insulin resistance index |
| Aoun et al. [24] (2022) |
The Interaction Between Genetic Polymorphisms in FTO, MC4R and MTHFR Genes and Adherence to the Mediterranean Diet in Relation to Obesity |
Cross-sectional |
rs17782313 (CC & TC) |
392 males and females, healthy |
Not clear |
No significant |
No significant association with waist circumference, waist-hip ratio, and body mass index |
| Mohammadi et al. [25] (2020) |
Dietary Patterns Interact With the Variations of 18q21. 23 rs17782313 Locus on the Regulation of Hypothalamic-Pituitary Axis Hormones and Cardio-Metabolic Risk Factors in Obesity |
Cross-sectional |
rs17782313 (CC) |
288 males and females, healthy |
20–50 ≥ 30 kg/m2
|
Negative |
↑Systolic blood pressure and agouti-related protein levels |
| Hosseininasab et al. [9] (2022) |
Are There Any Interactions Between Modified Nordic-Style Diet Score and MC4R Polymorphism on Cardiovascular Risk Factors Among Overweight and Obese Women? |
Cross-sectional |
rs17782313 (CC & TC) |
282 females, healthy |
18–48 ≥ 25 kg/m2
|
Positive |
↓Visceral fat level, total cholesterol, and low-density lipoprotein cholesterol levels |
| Yarizadeh et al. [10] (2021) |
The Interaction Between the Dietary Inflammatory Index and MC4R Gene Variants on Cardiovascular Risk Factors |
Cross-sectional |
rs17782313 (CC) |
266 females, healthy |
18–56, 25–45 kg/m2
|
Positive |
↑Higher high-density lipoprotein cholesterol levels |
| ↓Low-density lipoprotein cholesterol and triglyceride levels |
| Yarizadeh et al. [26] (2020) |
The Interaction Between Dietary Approaches to Stop Hypertension and MC4R Gene Variant in Predicting Cardiovascular Risk Factors |
Cross-sectional |
rs17782313 (CC) |
266 females, healthy |
18–50, 25–40 kg/m2
|
Positive |
↓Systolic blood pressure and diastolic blood pressure |
