Extended Data Fig. 3. Similarities between changes in Rragc-mutant mice and physiological aging in mice and humans.
a. Gene set enrichment analysis (GSEA) related to TFEB target genes in kidneys for CNIO cohort from 16-month-old wt (n = 5) versus 3-month-old (n = 4) mice. b. Gene set enrichment analysis (GSEA) related to TFEB target genes in kidneys for NIA cohort from 24-month-old wt (n = 5) versus 2-month-old (n = 5) mice. c. qRT–PCR analysis of TFEB target in kidney from 3-month-old wt (n = 8) and 16-month-old wt (n = 7) male mice. Statistical significance was calculated by two-way ANOVA. Data are presented as mean values ± SD. d. Gene set enrichment analysis (GSEA) related to TFEB target genes in PBMCs for the Spanish Centenarian Study Group (SCSG) cohort (Borras et al. 2016) from Septuagenarians (74-75 yr old) (n = 10) versus Young (24-41 yr old) (n = 10) individuals.