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. 2024 Jun 7;4(8):1102–1120. doi: 10.1038/s43587-024-00635-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a. Representative images from anti-MPO and anti-CD45 immunostainings of kidneys harvested from 8-15-week-old Rragc^+/+ and Rragc^S74N/+ male mice. Bars represent 50 μm b. Representative images from anti-MPO and anti-CD45 immunostainings of livers harvested from 8-15-week-old Rragc^+/+and Rragc^S74N/+ male mice. Bars represent 50 μm. c. Principal component analysis (PCA) from the RNA-seq performed from kidney samples from 3-month-old Rragc^+/+ (n = 5) and Rragc^S74N/+ (n = 5) mice. d. Gene set enrichment analysis (GSEA) related to inflammatory signatures, TFEB target genes, and mTORC1 signaling associated genes in kidneys from 3-month-old Rragc^S74N/+ (n = 5) versus Rragc^+/+ (n = 5) mice. e. Principal component analysis (PCA) from the RNA-seq performed from liver samples from 3-month-old Rragc^+/+ (n = 4) and Rragc^S74N/+ (n = 4) mice. f. Gene set enrichment analysis (GSEA) related to inflammatory signatures and mTORC1 signaling associated genes in livers from 2–3.5-month-old Rragc^S74N/+ (n = 4) versus Rragc^+/+ (n = 4) mice.