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. 1989 Sep 15;262(3):747–751. doi: 10.1042/bj2620747

Phosphoinositide hydrolysis in mitogen-stimulated human peripheral-blood T lymphocytes.

S King 1, G Whitley 1, M Salmon 1, A Johnstone 1
PMCID: PMC1133337  PMID: 2556109

Abstract

Both phytohaemagglutinin and antibodies to the CD3 molecule induced proliferation and phosphoinositide hydrolysis in human peripheral-blood T lymphocytes, but the magnitude of the inositol phosphate response was small and the rate of accumulation slow [significant increases in Ins(1,4,5)P3 were observed only after 10 min]. Hence this response differs from the well-characterized Ins(1,4,5)P3 responses of many other systems. This slow response, its abrogation in Ca2+-depleted medium, the slow and maintained increase in Ca2+ as measured by Quin-2, and the ability of the Ca2+ ionophore A23187 to stimulate Ins(1,4,5)P3 accumulation all suggest that the increase in Ins(1,4,5)P3 occurs, at least in part, as a result of receptor-mediated Ca2+ influx in mitogen-stimulated T lymphocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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