Table 3.
Predictors of recurrence with univariate Cox regression.
| Recurrence | Local recurrence | Neck recurrence or mets | ||||
|---|---|---|---|---|---|---|
| p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | |
| Age (years) | 0.53 | 1.00 (0.99, 1.01) | 0.584 | 1.00 (0.99, 1.01) | 0.63 | 1.00 (0.99, 1.00) |
| Male | 0.843 | 1.01 (0.87, 1.19) | 0.569 | 1.04 (0.91, 1.19) | 0.75 | 0.98 (0.86, 1.11) |
| Female | 0.98 (0.84, 1.15) | 0.96 (0.84, 1.10) | 1.02 (0.90, 1.16) | |||
| Smoking | 0.329 | 1.08 (0.92, 1.27) | 0.328 | 1.07 (0.93, 1.22) | 0.91 | 1.01 (0.89, 1.15) |
| Alcohol | 0.947 | 0.99 (0.84, 1.18) | 0.638 | 0.97 (0.85, 1.10) | 0.36 | 0.94 (0.82, 1.08) |
| pT1 | *0.030 | 0.85 (0.73, 0.98) | *0.011 | 0.85 (0.75, 0.96) | 0.7 | 0.96 (0.86, 1.11) |
| pT2 | 1.18 (1.02, 1.37) | 1.18 (1.04, 1.34) | 1.02 (0.90, 1.16) | |||
| pN0 | *0.013 | 0.81 (0.69, 0.96) | 0.132 | 0.90 (0.78, 1.03) | 0.08 | 0.89 (0.78, 1.01) |
| pN1 | 1.23 (1.05, 1.44) | 1.11 (0.97, 1.28) | 1.13 (0.99, 1.29) | |||
| pN2 | ||||||
| Margin + | 0.455 | 1.12 (0.83, 1.51) | 0.849 | 1.02 (0.79, 1.32) | 0.78 | 1.04 (0.81, 1.32) |
| PNI | 0.26 | 0.90 (0.74, 1.08) | 0.698 | 0.97 (0.83, 1.14) | 0.07 | 0.87 (0.75, 1.01) |
| LVI | 0.506 | 1.08 (0.85, 1.37) | 0.6 | 1.05 (0.86, 1.29) | 0.51 | 1.07 (0.88, 1.29) |
| Poor diff | 0.682 | 1.04 (0.87, 1.24) | 0.932 | 1.01 (0.86, 1.17) | 0.79 | 1.02 (0.88, 1.18) |
| ECS | *0.014 | 1.42 (1.08, 1.86) | *0.021 | 1.32 (1.04, 1.67) | 0.19 | 1.16 (0.93, 1.46) |
| >4 nodes | *0.001 | 1.68 (1.23, 2.28) | *0.003 | 1.50 (1.15, 1.95) | 0.07 | 1.27 (0.98, 1.64) |
| Radiation | 0.259 | 1.10 (0.93, 1.29) | 0.501 | 1.05 (0.91, 1.20) | 0.291 | 1.06 (0.95, 1.19) |
| Chemotherapy | 0.677 | 0.94 (0.71, 1.25) | 0.281 | 0.88 (0.69, 1.11) | 0.629 | 1.05 (0.86, 1.28) |
Mets, metastasis; HR, hazards ratio; CI, confidence interval; PNI, perineural invasion; LVI, lymphovascular invasion; Poor diff, poorly differentiated; ECS, extracapsular spread.
Significant results are indicated by asterisks.