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. 2024 Aug 19;14:19216. doi: 10.1038/s41598-024-70249-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Associations between the female age and pregnancy outcomes in patients who received their first eSET. A threshold, nonlinear association between the female age and CPR (a) and OPR (b) was found in a generalized additive model (GAM). The solid radial line depicts the continuous curve that best fits the relationship between the variables. The blue bars depict the 95% confidence interval derived from the fit. Adjust for infertility years, types of fertilization, infertility factors, AMH, COS protocols, frozen embryos, embryo type, and endometrial thickness. The two arcs represent a smooth curve fit between age and CPR (c) and OPR (d), stratified by whether the transplanted embryos are cleavage stage embryos or blastocysts. The colored bands represent 95% confidence intervals for the fit. Adjust for infertility years, types of fertilization, infertility factors, AMH, COS protocols, frozen embryos, embryo type, and endometrial thickness.