Table 2.
Distribution of alleles and genotypes of IL-10 gene SNPs among CRC, colon cancer, rectum cancer cases, and healthy subjects.
| Genetic Model | CRC cases N(%) | Colon cancer cases N(%) | Rectum cancer cases N(%) | HS N (%) | P1 | OR1 (95%CI) | P2 | OR2 (95%CI) | P3 | OR3 (95%CI) | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| −1082 A/G (rs1800896) |
Allele model | 0.67 | 1.07(0.77–1.51) | 0.17 | 1.34(0.88–2.06) | 0.44 | 0.85(0.56–1.29) | ||||
| A | 162(62) | 93(67) | 69(57) | 200 (60) | |||||||
| G | 98(38) | 45(33) | 53(43) | 130 (40) | |||||||
| Dominant model | 0.43 | 0.82(0.51–1.35) | 0.71 | 1.11(0.61–1.96) | 0.08 | 0.55(0.28–1.06) | |||||
| AA | 40(31) | 26(38) | 14(23) | 58 (35) | |||||||
| GG + AG | 90(69) | 43(62) | 47(77) | 107 (65) | |||||||
| Recessive model | 0.03 | 0.44(0.21–0.93) | 0.01 | 0.18(0.04–0.72) | 0.41 | 0.67(0.27–1.64) | |||||
| GG | 8(6) | 2(3) | 6(10) | 23 (14) | |||||||
| AA + AG | 122(94) | 67(97) | 55(90) | 142 (86) | |||||||
| Codominant Model | 0.04 | 1.65(1.02–2.63) | 0.23 | 1.41(0.79–2.49) | 0.03 | 1.98(1.07–3.70) | |||||
| AG | 82(63) | 41(59) | 41(67) | 84 (51) | |||||||
| AA + GG | 48(37) | 28(41) | 20(33) | 81 (49) | |||||||
| Homozygote model | 0.13 | 1.98(0.84–4.73) | 0.02 | 5.16(1.31–23.26) | 0.89 | 0.93(0.31–2.77) | |||||
| AA | 40(83) | 26(93) | 14(70) | 58 (72) | |||||||
| GG | 8(17) | 2(7) | 6(30) | 23 (28) | |||||||
| Heterozygote model | 0.18 |
0.71(0.42–1.16) |
0.78 |
0.92(0.52–1.65) |
0.04 |
0.49(0.24–0.99) |
|||||
| AA | 40 (33) | 26(39) | 14(25) | 58 (41) | |||||||
| AG |
82 (67) |
41(61) |
41(75) |
84 (59) |
|||||||
| 592 A C (rs1800872) −592 A/C (rs1800872) |
Allele model | 0.90 | 1.02(0.73–1.43) | 0.76 | 1.07(0.70–1.63) | 0.91 | 0.98(0.62–1.52) | ||||
| A | 88(34) | 48(35) | 40(33) | 110 (33) | |||||||
| C | 172(66) | 90(65) | 82(67) | 220 (67) | |||||||
| Recessive model | 0.09 | 1.76(0.88–3.43) | 0.10 | 1.90(0.88–4.11) | 0.27 | 1.60(0.70–3.79) | |||||
| AA | 23(18) | 13(19) | 10(16) | 18 (11) | |||||||
| AC + CC | 107(82) | 56(81) | 51(84) | 147 (90) | |||||||
| Dominant model | 0.33 | 1.26(0.79–2.02) | 0.48 | 1.22(0.70–2.12) | 0.38 | 1.30(0.72–2.36) | |||||
| CC | 65(50) | 34(49) | 31(51) | 73 (44) | |||||||
| AA + AC | 65 (50) | 35(51) | 30(49) | 92 (56) | |||||||
| Co-dominant Model | 0.03 | 0.59(0.36–0.94) | 0.07 | 0.58(0.32–1.06) | 0.10 | 0.60(0.32–1.11) | |||||
| AC | 42(32) | 22(32) | 20(33) | 74 (45) | |||||||
| AA + CC | 88(68) | 47(68) | 41(67) | 91 (55) | |||||||
| Homozygote model | 0.31 | 1.44(0.71–2.79) | 0.29 | 1.55(0.67–3.38) | 0.55 | 1.31(0.53–3.12) | |||||
| AA | 23(26) | 13(28) | 10(25) | 18 (20) | |||||||
| CC | 65(74) | 34(72) | 31(75) | 73 (80) | |||||||
| Heterozygote model | 0.08 | 0.64 (0.38–1.04) | 0.16 | 0.64 (0.34–1.22) | 0.17 | 0.64 (0.34–1.21) | |||||
| AC | 42(39) | 22(39) | 20(39) | 74 (50.3) | |||||||
| CC | 65(61) | 34(61) | 31(61) | 73 (49.7) | |||||||