Table 4.
Distribution of diplotypes of IL-10 gene SNPs between CRC, colon cancer, rectum cancer cases, and HS.
| Diplotypes | CRC cases N (%) |
Colon cancer cases N (%) | Rectum cancer cases N (%) | HS N (%) |
P1 | OR1 (95%CI) | P2 | OR2 (95%CI) | P3 | OR3 (95%CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| Hap1/Hap1 vs. | 16 (12) | 12 (17) | 4 (7) | 15 (9) | 0.37 | 1.40 (0.67–3.00) | 0.07 | 2.10 (0.90–4.60) | 0.54* | 0.70 (0.25–2.10) |
| Hap1/others + Others/others | 114 (88) | 57 (83) | 57 (93) | 150 (91) | ||||||
| Hap2/Hap2 vs. | 14 (11) | 7 (10) | 7 (11) | 15 (9) | 0.63 | 1.21 (0.59–2.67) | 0.80 | 1.13 (0.44–2.93) | 0.59 | 1.30 (0.51–3.04) |
| Hap2/others + Others/others | 116 (89) | 62 (90) | 54 (89) | 150 (91) | ||||||
| Hap3/Hap3 vs. | 6 (5) | 0 (0) | 6 (10) | 20 (12) | 0.02 | 0.35 (0.14–0.85) | – | – | 0.63 | 0.79 (0.31–1.99) |
| Hap3/others + Others/others | 124 (95) | 69 (100) | 55 (90) | 145 (88) |
HS: healthy subjects. N: Number. OR: odds ratio. 95%CI: confidence interval.
P-values are estimated by the chi-square test or the Fisher's exact test when appropriate.
P1 and OR1: CRC cases vs. HS, P2, and OR2: Colon cancer cases vs. HS, P3 and OR3: Rectum cancer cases vs. HS.
Significant P-values are represented in Bold.