Fig. 9.

Stability results of Gd-BOPTA-BrCy112-nEGs up to 7 days post-fabrication. (a) Time-dependent absorption spectra of Gd-BOPTA-BrCy112-nEGs pellets and their corresponding supernatants (Sup) immediately after fabrication (day 0) and at days 2 and 7 of storage at 4°C. (b) Fluorescence emission spectra and (c) normalized spectrally integrated fluorescence values ($\sigma$) over the 765 to 900-nm band in response to photoexcitation at $750\pm 2.5\mathrm{nm}$. (d) Fluorescence quantum yield ($\varphi$) for Gd-BOPTA-BrCy112-nEGs at days 0, 2, and 7 relative to that of $6.45\mu \mathrm{M}$ free ICG in water at 780 nm. (e) MR images of Gd-BOPTA standards at different concentrations and Gd-BOPTA-BrCy112-nEGs at days 0, 2, and 7. (f) $T_1$ relaxation rate (R1) of Gd-BOPTA-BrCy112-nEGs. Each data point is an average of three independent measurements.