Table 2. Mean Change in ADPS From Baseline at Week 13 (Full Analysis Set)^a.

Stage 1 hypothesis	P value	w1	Stage 2 hypothesis	P value	w2	Combined P value
HSK16149 study dose, 40 mg/d
H1234: p1234,1	.60	0.58	H1234: p12,2	<.001	0.81	<.001
H123: p123,1	.54	0.58	H123: p12,2	<.001	0.81	<.001
H124: p124,1	.54	0.58	H124: p12,2	<.001	0.81	<.001
H134: p134,1	.54	0.58	H134: p1,2	<.001	0.81	<.001
H12: p12,1	.45	0.58	H12: p12,2	<.001	0.81	<.001
H13: p13,1	.45	0.58	H13: p1,2	<.001	0.81	<.001
H14: p14,1	.45	0.58	H14: p1,2	<.001	0.81	<.001
H1: p1,1	.31	0.58	H1: p1,2	<.001	0.81	<.001
HSK16149 study dose, 80 mg/d
H1234: p1234,1	.60	0.58	H1234: p12,2	<.001	0.81	<.001
H123: p123,1	.54	0.58	H123: p12,2	<.001	0.81	<.001
H124: p124,1	.54	0.58	H124: p12,2	<.001	0.81	<.001
H234: p234,1	.70	0.58	H234: p2,2	<.001	0.81	<.001
H12: p12,1	.45	0.58	H12: p12,2	<.001	0.81	<.001
H23: p23,1	.62	0.58	H23: p2,2	<.001	0.81	<.001
H24: p24,1	.61	0.58	H24: p2,2	<.001	0.81	<.001
H2: p2,1	.51	0.58	H2: p2,2	<.001	0.81	<.001

Abbreviation: ADPS, average daily pain score.

^a Missing week 13 ADPSs were calculated based on multiple fill (multiple imputation) for filling. H is statistical hypothesis test; p is the P value of test H; wj (j = 1 or 2) is the weight of the first and second stages given in advance, satisfying 0 ≤ wj ≤ 1 and w1² + w2² = 1 (w1² + w2² = 1: w1² plus w2² is equal to 1).