Table 1.
League table for clinical outcomes
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League table
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| OS | |||||||||||
| HAIC + Lenv + A | 0.42 (0.12; 1.44) | ||||||||||
| 0.58 (0.09; 3.84) | HAIC + A | 0.38 (0.12; 1.17) | |||||||||
| 0.42 (0.12; 1.44) | 0.73 (0.17; 3.08) | HAIC + Lenv | 0.52 (0.21; 1.28) | ||||||||
| 0.36 (0.05; 2.31) | 0.61 (0.13; 2.93) | 0.84 (0.20; 3.46) | HAIC + PD-1 | 0.62 (0.21; 1.84) | |||||||
| 0.24 (0.05; 1.17) | 0.41 (0.12; 1.39) | 0.56 (0.20; 1.56) | 0.66 (0.20; 2.20) | HAIC + Sora | 0.43 (0.12; 1.47) | 0.58 (0.36; 0.94) | |||||
| 0.24 (0.04; 1.63) | 0.42 (0.08; 2.09) | 0.58 (0.13; 2.47) | 0.68 (0.14; 3.32) | 1.03 (0.31; 3.43) | HAIC + RT | 0.50 (0.16; 1.52) | |||||
| 0.22 (0.05; 1.01) | 0.38 (0.12; 1.17) | 0.52 (0.21; 1.28) | 0.62 (0.21; 1.84) | 0.94 (0.57; 1.55) | 0.91 (0.29; 2.85) | HAIC | 0.53 (0.40; 0.70) | 0.50 (0.33; 0.75) | 0.32 (0.11; 0.95) | ||
| 0.12 (0.03; 0.57) | 0.21 (0.07; 0.67) | 0.29 (0.11; 0.74) | 0.34 (0.11; 1.05) | 0.52 (0.33; 0.81) | 0.50 (0.16; 1.52) | 0.55 (0.42; 0.72) | Sora | ||||
| 0.11 (0.01; 0.84) | 0.18 (0.03; 1.10) | 0.25 (0.05; 1.33) | 0.30 (0.05; 1.76) | 0.45 (0.10; 2.00) | 0.44 (0.07; 2.66) | 0.48 (0.12; 1.95) | 0.88 (0.21; 3.63) | HAIC + TACE + S-1 | 1.00 (0.35; 2.86) | ||
| 0.11 (0.02; 0.63) | 0.18 (0.04; 0.78) | 0.25 (0.07; 0.91) | 0.30 (0.07; 1.24) | 0.45 (0.16; 1.29) | 0.44 (0.10; 1.90) | 0.48 (0.19; 1.21) | 0.88 (0.34; 2.28) | 1.00 (0.35; 2.86) | HAIC + TACE | 1.03 (0.45; 2.34) | |
| 0.11 (0.02; 0.53) | 0.19 (0.06; 0.63) | 0.26 (0.10; 0.70) | 0.31 (0.10; 0.99) | 0.47 (0.24; 0.90) | 0.45 (0.13; 1.52) | 0.50 (0.33; 0.75) | 0.90 (0.55; 1.47) | 1.03 (0.27; 3.91) | 1.03 (0.45; 2.34) | TACE | |
| 0.07 (0.01; 0.46) | 0.12 (0.03; 0.58) | 0.17 (0.04; 0.68) | 0.20 (0.04; 0.92) | 0.30 (0.09; 0.99) | 0.29 (0.06; 1.40) | 0.32 (0.11; 0.95) | 0.58 (0.19; 1.77) | 0.66 (0.11; 3.87) | 0.66 (0.16; 2.73) | 0.64 (0.20; 2.04) | BSC |
| PFS | |||||||||||
| HAIC + A | 0.49 (0.17; 1.39) | ||||||||||
| 0.96 (0.17; 5.46) | HAIC + Lenv + A | 0.46 (0.16; 1.36) | |||||||||
| 0.85 (0.16; 4.50) | 0.89 (0.13; 5.94) | HAIC + TACE + S-1 | 0.90 (0.31; 2.59) | ||||||||
| 0.77 (0.21; 2.77) | 0.80 (0.17; 3.87) | 0.90 (0.31; 2.59) | HAIC + TACE | 0.39 (0.22; 0.70) | |||||||
| 0.75 (0.17; 3.29) | 0.78 (0.14; 4.44) | 0.88 (0.17; 4.61) | 0.97 (0.27; 3.50) | HAIC + PD-1 | 0.65 (0.23; 1.85) | ||||||
| 0.53 (0.10; 2.70) | 0.55 (0.09; 3.58) | 0.62 (0.10; 3.73) | 0.69 (0.16; 2.94) | 0.71 (0.14; 3.61) | HAIC + RT | 0.47 (0.14; 1.52) | |||||
| 0.49 (0.17; 1.39) | 0.51 (0.13; 2.04) | 0.57 (0.16; 2.07) | 0.63 (0.30; 1.32) | 0.65 (0.23; 1.85) | 0.92 (0.26; 3.21) | HAIC | 0.91 (0.38; 2.16) | 0.62 (0.39; 0.98) | 0.51 (0.33; 0.78) | ||
| 0.44 (0.11; 1.72) | 0.46 (0.16; 1.36) | 0.52 (0.11; 2.45) | 0.57 (0.18; 1.80) | 0.59 (0.15; 2.30) | 0.84 (0.18; 3.83) | 0.91 (0.38; 2.16) | HAIC + Lenv | ||||
| 0.39 (0.11; 1.32) | 0.40 (0.09; 1.86) | 0.45 (0.11; 1.91) | 0.50 (0.19; 1.34) | 0.52 (0.15; 1.76) | 0.73 (0.20; 2.61) | 0.79 (0.42; 1.51) | 0.87 (0.30; 2.57) | HAIC + Sora | 0.64 (0.40; 1.03) | ||
| 0.30 (0.10; 0.95) | 0.31 (0.07; 1.36) | 0.35 (0.11; 1.18) | 0.39 (0.22; 0.70) | 0.40 (0.13; 1.26) | 0.57 (0.15; 2.16) | 0.62 (0.39; 0.98) | 0.68 (0.26; 1.82) | 0.78 (0.36; 1.72) | TACE | ||
| 0.25 (0.08; 0.77) | 0.26 (0.06; 1.10) | 0.29 (0.07; 1.12) | 0.32 (0.14; 0.75) | 0.33 (0.11; 1.02) | 0.47 (0.14; 1.52) | 0.51 (0.33; 0.78) | 0.56 (0.21; 1.47) | 0.64 (0.40; 1.03) | 0.82 (0.44; 1.53) | Sora | |
| CR | |||||||||||
| HAIC + Sora | 6.21 (0.28; 138.56) | 6.77 (2.11; 21.68) | |||||||||
| 1.46 (0.02; 90.79) | HAIC + PD-1 | 1.82 (0.04; 92.69) | |||||||||
| 2.27 (0.22; 22.94) | 1.55 (0.02; 123.86) | HAIC + TACE + S-1 | 1.10 (0.26; 4.62) | ||||||||
| 2.49 (0.41; 15.27) | 1.70 (0.03; 106.73) | 1.10 (0.26; 4.62) | HAIC + TACE | 3.30 (1.20; 9.03) | |||||||
| 2.66 (0.75; 9.46) | 1.82 (0.04; 92.69) | 1.17 (0.17; 8.14) | 1.07 (0.29; 3.91) | HAIC | 1.93 (0.09; 42.76) | 2.13 (0.32; 14.10) | 3.01 (1.41; 6.41) | 3.08 (1.36; 6.98) | |||
| 5.15 (0.18; 146.19) | 3.52 (0.02; 524.16) | 2.27 (0.06; 87.52) | 2.07 (0.07; 59.37) | 1.93 (0.09; 42.76) | BSC | ||||||
| 5.67 (0.58; 55.24) | 3.87 (0.05; 303.50) | 2.50 (0.17; 37.42) | 2.27 (0.23; 22.55) | 2.13 (0.32; 14.10) | 1.10 (0.03; 41.42) | HAIC + Lenv | |||||
| 7.62 (2.55; 22.77) | 5.21 (0.10; 283.99) | 3.36 (0.42; 26.67) | 3.06 (0.69; 13.61) | 2.86 (1.37; 5.98) | 1.48 (0.06; 35.69) | 1.35 (0.18; 10.25) | Sora | ||||
| 8.21 (1.82; 37.10) | 5.62 (0.10; 310.71) | 3.62 (0.63; 20.94) | 3.30 (1.20; 9.03) | 3.08 (1.36; 6.98) | 1.59 (0.06; 39.20) | 1.45 (0.18; 11.38) | 1.08 (0.36; 3.24) | TACE | |||
| PR | |||||||||||
| HAIC + TACE + S-1 | 2.34 (0.86; 6.40) | ||||||||||
| 1.59 (0.42; 6.00) | HAIC + Lenv | 1.54 (0.92; 2.56) | |||||||||
| 1.72 (0.44; 6.65) | 1.08 (0.50; 2.33) | HAIC + PD-1 | 1.42 (0.80; 2.51) | ||||||||
| 2.34 (0.86; 6.40) | 1.48 (0.62; 3.53) | 1.36 (0.55; 3.37) | HAIC + TACE | 2.16 (1.14; 4.08) | |||||||
| 2.42 (0.61; 9.51) | 1.52 (0.69; 3.37) | 1.41 (0.61; 3.23) | 1.03 (0.41; 2.62) | HAIC + Sora | 5.00 (1.19; 21.04) | 4.50 (2.71; 7.48) | |||||
| 2.44 (0.72; 8.32) | 1.54 (0.92; 2.56) | 1.42 (0.80; 2.51) | 1.04 (0.51; 2.11) | 1.01 (0.55; 1.85) | HAIC | 2.07 (1.54; 2.80) | 4.62 (0.24; 89.16) | 6.32 (4.08; 9.80) | |||
| 5.05 (1.54; 16.61) | 3.18 (1.76; 5.76) | 2.94 (1.55; 5.59) | 2.16 (1.14; 4.08) | 2.09 (1.06; 4.12) | 2.07 (1.54; 2.80) | TACE | |||||
| 11.28 (0.46; 277.69) | 7.10 (0.35; 143.15) | 6.56 (0.32; 133.57) | 4.81 (0.23; 100.83) | 4.67 (0.23; 95.70) | 4.62 (0.24; 89.16) | 2.23 (0.11; 43.69) | BSC | ||||
| 13.29 (3.63; 48.61) | 8.37 (4.32; 16.23) | 7.73 (3.81; 15.68) | 5.67 (2.49; 12.89) | 5.50 (3.40; 8.89) | 5.45 (3.57; 8.30) | 2.63 (1.57; 4.41) | 1.18 (0.06; 23.41) | Sora | |||
| ORR | |||||||||||
| HAIC + TACE + S-1 | 1.99 (0.40; 9.99) | ||||||||||
| 1.28 (0.12; 14.33) | HAIC + Lenv | 1.95 (0.51; 7.44) | |||||||||
| 1.76 (0.15; 21.24) | 1.37 (0.19; 10.05) | HAIC + PD-1 | 1.42 (0.33; 6.19) | ||||||||
| 1.96 (0.21; 18.19) | 1.53 (0.29; 7.97) | 1.11 (0.19; 6.47) | HAIC + Sora | 8.00 (1.08; 59.18) | 6.08 (2.38; 15.59) | ||||||
| 1.99 (0.40; 9.99) | 1.55 (0.26; 9.34) | 1.13 (0.17; 7.53) | 1.02 (0.22; 4.74) | HAIC + TACE | 3.97 (1.43; 11.04) | ||||||
| 2.50 (0.34; 18.61) | 1.95 (0.51; 7.44) | 1.42 (0.33; 6.19) | 1.28 (0.48; 3.37) | 1.26 (0.38; 4.15) | HAIC | 1.93 (0.07; 56.84) | 3.16 (1.71; 5.85) | 8.36 (4.66 15.01) | |||
| 4.84 (0.09; 246.61) | 3.77 (0.10; 143.00) | 2.74 (0.07; 109.59) | 2.47 (0.07; 83.18) | 2.43 (0.07; 87.58) | 1.93 (0.07; 56.84) | BSC | |||||
| 7.91 (1.17; 53.36) | 6.16 (1.41; 26.89) | 4.48 (0.91; 22.12) | 4.04 (1.28; 12.73) | 3.97 (1.43; 11.04) | 3.16 (1.71; 5.85) | 1.63 (0.05; 50.80) | TACE | ||||
| 17.88 (2.22; 143.80) | 13.92 (3.25; 59.60) | 10.14 (2.09; 49.09) | 9.13 (3.87; 21.51) | 8.97 (2.39; 33.65) | 7.15 (4.06; 12.58) | 3.70 (0.12; 113.89) | 2.26 (0.98; 5.22) | Sora | |||
| DCR | |||||||||||
| HAIC + TACE + S-1 | 2.04 (0.55; 7.61) | ||||||||||
| 1.17 (0.15; 9.35) | HAIC + PD-1 | 2.52 (0.72; 8.81) | |||||||||
| 2.04 (0.55; 7.61) | 1.74 (0.35; 8.65) | HAIC + TACE | 3.87 (1.64; 9.11) | ||||||||
| 2.95 (0.56; 15.45) | 2.52 (0.72; 8.81) | 1.45 (0.53; 3.94) | HAIC | 1.40 (0.45; 4.37) | 0.06 (0.00; 1.40) | 1.71 (0.33; 8.88) | 2.67 (1.59; 4.50) | 3.02 (2.08; 4.40) | |||
| 4.14 (0.56; 30.84) | 3.53 (0.65; 19.15) | 2.03 (0.45; 9.24) | 1.40 (0.45; 4.37) | HAIC + Lenv | |||||||
| 4.38 (0.71; 26.90) | 3.73 (0.87; 16.04) | 2.15 (0.62; 7.49) | 1.48 (0.70; 3.13) | 1.06 (0.27; 4.11) | HAIC + Sora | 1.68 (0.86; 3.29) | |||||
| 5.05 (0.49; 52.13) | 4.30 (0.54; 34.07) | 2.47 (0.36; 17.01) | 1.71 (0.33; 8.88) | 1.22 (0.16; 9.01) | 1.15 (0.19; 7.03) | BSC | |||||
| 7.89 (1.64; 37.97) | 6.73 (1.73; 26.11) | 3.87 (1.64; 9.11) | 2.67 (1.59; 4.50) | 1.90 (0.55; 6.64) | 1.80 (0.73; 4.48) | 1.56 (0.28; 8.79) | TACE | ||||
| 8.52 (1.56; 46.49) | 7.26 (1.97; 26.84) | 4.18 (1.43; 12.17) | 2.89 (1.99; 4.19) | 2.06 (0.62; 6.80) | 1.95 (1.01; 3.75) | 1.69 (0.31; 9.14) | 1.08 (0.57; 2.05) | Sora | |||
HAIC: Hepatic arterial infusion chemotherapy; Sora: Sorafenib; Lenv: Lenvatinib; TACE: Transarterial chemoembolization; RT: Radiotherapy; S-1: A composite preparation of a 5-fluorouracil prodrug; A: Ablation; PD-1: Programmed death 1; BSC: Best supportive care.