Table 5.

Binding information for curcumin and docking of the hub target molecules

Hub targets	Binding energy (kcal/mol)	Hydrogen bonds				Hydrogen bonds, lengths
ESR1	-6.3	Ala307 (A)	Gly366 (A)		Ser305 (A)	2.82Å	3.06Å	2.95Å	3.47Å
EGFR	-7.8	Lys745 (A)				3.31Å
CYP3A4	-8.4	-				-
MAPK14	-7.9	Lys53 (A)				3.22Å
CYP1A2	-9.5	Arg108 (A)		Arg456 (A)		3.15Å		3.15Å
CYP2B6	-9.3	Arg98 (A)				2.95Å		2.96Å

ESR1: Estrogen receptor 1; EGFR: Epidermal growth factor receptor; CYP3A4: Cytochrome P450 family 3 subfamily A member 4; MAPK14: Mitogen-activated protein kinase 14; CYP1A2: Cytochrome P450 family 1 subfamily A member 2; CYP2B6: Cytochrome P450 family 2 subfamily B member 6.