Table 1. Blood biochemical analyses and enzyme activities in the rat serum.
Assays | Units | Control | STZ | STZ/IN-1 | STZ/IN-2 |
ALT | μkat/l | 0.81 ± 0.37 | 2.14 ± 0.53* | 1.31 ± 0.44 (1.72 ± 0.51) | 1.07 ± 0.38** (1.20 ± 0.35) |
AST | μkat/l | 1.93 ± 0.70 | 6.32 ± 1.30* | 3.75 ± 0.94** (4.24 ± 0.98) | 2.96 ± 0.86** (3.47 ± 0.88**) |
TG | mg/l | 1 338 ± 215 | 2 899 ± 434* | 2 048 ± 389 (2 295 ± 406) | 1 897 ± 402** (1 718 ± 314**) |
Ketones | mmol/l | 242 ± 58 | 1 224 ± 297* | 661 ± 183** (890 ± 208) | 504 ± 157** (774 ± 181) |
Albumin | g/l | 43 ± 5 | 39 ± 3 | ND | ND |
Glucose | g/l | 1 060 ± 320 | 4 780 ± 1 120* | 4 420 ± 950* (ND) | 4 530 ± 1 040* (ND) |
One μkat corresponds to the amount of ALT or AST required to generate 1.0 μmole of pyruvate or glutamate per minute at 37°C, respectively
STZ/IN-1 and STZ/IN-2 represent one (1.0 ml at 196 mg/ml) and two consecutive infusions of albumin, respectively
*P < 0.05 compared with that of control; **P < 0.05 compared with that of STZ
ND = not determined; STZ = streptozotocin; TG = triglycerides