Figure 4.

(A) A histogram of maximized efficiencies as defined in Eq. (1) for 10,000 random initial guesses. The vertical red line represents the efficiency of the mouse hypothalamus using the measurements derived from the Allen Brain Atlas. This figure indicates that the hypothalamus is organized such that Eq. (1) is among the highest values that are possible although it is not the unique efficient packing. The configurations on the left and right show example configurations from different low- and high-efficiency bins. Two different hypothalamus sub-regions are highlighted in green and red to show their changes in position. (B) The histogram of efficiencies of 48,300 randomly packed hypothalamus sub-regions superimposed upon histogram from panel (A). These configurations are randomly generated and not optimized for efficiency. Comparing the two histograms shows that the true network is among the most efficient of optimized networks, which together are more efficient than an ensemble of randomly configured theoretical hypothalamic networks.