Treating investigator–reported GAIS responder rate at each study visit following HAEYE treatment (observed cases; ITT population). A responder was defined as a patient who indicated that their appearance was “improved,” “much improved,” or “very much improved” on the GAIS. An optional additional HAEYE treatment was offered at Month 12 to patients already treated at baseline in whom optimal aesthetic improvement had not been maintained, and to patients in the control group. Only patients who had HAEYE retreatment/treatment at Month 12 attended visits at Months 13, 15 and 18 (corresponding to 1, 3, and 6 months after retreatment/treatment at Month 12). The ITT population included all patients who were randomized at baseline. HAEYE-pooled included all patients receiving HAEYE treatment by needle or cannula. GAIS, Global Aesthetic Improvement Scale; HAEYE, Restylane Eyelight hyaluronic acid treatment; ITT, intention-to-treat.