Table 3.

Injection Volumes at Baseline Treatment and Touch-up (Safety Population)

	Injection volume, mL
	HAEYE-needle (n = 163)	HAEYE-cannula (n = 153)	HAEYE-pooled (n = 316)
Baseline treatment
n	146	138	284
Mean (SD)	1.3 (0.4)	1.4 (0.5)	1.3 (0.5)
Median	1.2	1.3	1.3
Min, max	0.4, 2.0	0.4, 2.0	0.4, 2.0
Optional touch-up
n	113	108	221
Mean (SD)	1.0 (0.5)	1.1 (0.5)	1.0 (0.5)
Median	1.0	1.0	1.0
Min, max	0.2, 2.0	0.2, 2.0	0.2, 2.0
Baseline treatment + touch-up
n	146	138	284
Mean (SD)	2.0 (0.8)	2.3 (0.9)	2.1 (0.9)
Median	2.0	2.0	2.0
Min, max	0.45, 4.0	0.4, 4.0	0.4, 4.0
Optional retreatment
n	88	76	164
Mean (SD)	1.0 (0.5)	1.2 (0.6)	1.1 (0.5)
Median	1.0	1.0	1.0
Min, max	0.2, 2.0	0.3, 2.0	0.2, 2.0
Optional first treatment (no-treatment control)
n	17	15	32
Mean (SD)	1.5 (0.6)	1.5 (0.5)	1.5 (0.5)
Median	1.7	1.5	1.6
Min, max	0.1, 2.0	0.5, 2.0	0.1, 2.0

Baseline treatment, optional touch-up treatment, and optional retreatment all refer to patients randomized to HA_EYE­ treatment at baseline. Optional baseline treatment only refers to those patients in the no-treatment control group at baseline who were offered HA_EYE treatment at Month 12. HA_EYE-pooled includes all patients receiving HA_EYE treatment by needle or cannula. HA_EYE, Restylane Eyelight hyaluronic acid treatment; max, maximum; min, minimum; SD, standard deviation.