Table 5.

Multivariate logistic regression model for factors associated with discontinuation of treatment.

Variable	OR	B	95% CI	p-Value
Age, years
⩾65		Ref
<65	1.115	0.109	0.464–2.679	0.808
Gender
Female		Ref
Male	1.257	0.229	0.658–2.402	0.489
Education status
Primary		Ref
Secondary	0.598	-0.515	0.238–1.503	0.274
Graduation	0.416	-0.878	0.183–0.943	0.036
Not available	1.446	0.369	0.611–3.421	0.402
BMI, kg/m2
⩾25		Ref
<25	2.358	0.858	1.164–4.777	0.017
Comorbidities
Diabetes		Ref
Absent	0.826	-0.191	0.358–1.907	0.654
Present
Respiratory disease
Absent		Ref
Present	0.534	-0.627	0.184–1.554	0.250
Autoimmune disease
Absent		Ref
Present	0.759	-0.276	0.290–1.987	0.574
No. of comorbidities
⩽2		Ref
>2	2.159	0.770	0.883–5.279	0.092
No. of concomitant medications
⩽2		Ref
>2	2.457	0.899	1.202–5.025	0.014
Age at diagnosis
Late onset (⩾40 years)		Ref
Early onset (40 years)	1.555	0.441	0.719–3.363	0.262
Type of monoclonal antibody
Fully human monoclonal antibody		Ref
Humanized monoclonal antibody	1.432	0.359	0.596–3.442	0.422
Length of treatment
Long term (⩾6 months)		Ref
Short term (<6 months)	9.180	2.217	4.909–17.165	<0.001
Hospitalizations during treatment
No		Ref
Yes	1.838	0.609	0.868–3.894	0.112

OR: odds ratio; CI: confidence interval; B: regression coefficient.