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. 2024 Jun 5;9(7):890–902. doi: 10.1016/j.jacbts.2024.04.006

Figure 3.

Figure 3

TPHi Attenuates Muscularization of Small Pulmonary Arteries and Cardiac Fibrosis in the SuHx Rat Model

(A to C) Representative images of small peripheral pulmonary arteries in hematoxylin and eosin (H&E), Masson’s Trichrome, and α-smooth muscle actin (SMA) staining, respectively. Scale bars: 25 μm. Bar graphs: (B) percentage of perivascular collagen. n = 20-40 vessels per animal; n = 7-8 animals. (C): Peripheral pulmonary artery muscularization. n = 20-40 vessels per animal; n = 7-8 animals. (D) Masson’s Trichrome staining of interstitial collagen in RV tissue. n = 4-7 individual animals. Mean ± SEM, ANOVA–Bonferroni post hoc test. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001.