Table 2.
Pharmacokinetic Profiles of Clopidogrel and C-AM According to CKD Status
| CKD | Patients Without CKD | P Value | |
|---|---|---|---|
| Clopidogrel | |||
| Tmax, h | 1.0 (1.0-2.0) | 1.0 (1.0-2.0) | 0.99 |
| Cmax, (ng/mL) | 21.3 (13.7-35.2) | 21.0 (11.1-33.8) | 0.88 |
| AUC0-last (ng·h/mL) | 58.0 (40.3-100.8) | 45.1 (24.7-93.7) | 0.25 |
| C-AM | |||
| Tmax, h | 1.0 (0.5-1.0) | 1.0 (0.5-1.0) | 0.49 |
| Cmax, (ng/mL) | 26.9 (19.1-31.4) | 22.6 (14.4-48.6) | 0.99 |
| AUC0-last (ng·h/mL) | 47.1 (32.8-62.7) | 39.6 (19.8-85.8) | 0.65 |
Values are median (25th-75th percentiles). Analyses done after a 600-mg loading dose from 0 to 6 hours. Tmax is reported as median (range). Cmax and AUC0-last are reported as geometric mean (range).
AUC0-last = area under the plasma concentration vs time curve from time 0 to the last measurable concentration; Cmax = maximum observed plasma concentration; Tmax = time to maximum observed plasma concentration; other abbreviations as in Table 1.