TABLE 3.
Definition of groups based on repetitive non-synonymous variations often seen in combination across replication-associated genesa
| Group name |
Variations in P | Variations in M2-1 | Variations in M2-2 | Variations in L |
|---|---|---|---|---|
| R1 | I66T/ P34L | N46S | G1725E/ H598Y/ D1731G/ V335I/ N215S | |
| R2 | T69I | C26Y | S1723G/ A1927T/ V1943D/ I139T/ T179A | |
| R3 | N174S/T180A/S182G | L37P | N143D/ T179S/ I1653V/K1661N/ S100L/ L953M/S1593N/ S1789F/ H1707Q/A2014/ Y2163N | |
| R4 | T92M | T79A | L835M/ A1537S/ N547S/P1720L/ V1943I | |
| R5 | N59S | R511K/ R1759K | ||
| R6 | No variations |
a
Variations included were observed in more than two sequences, and the groups shown account for all 109 RSV A sequences. N is not included here as there was no significant recurrence of non-synonymous variations observed. Within each CDS, a slash “/” indicates another variation seen in the group. For detailed associations, see Table S4.