TABLE 4.

Important amino acid residue information involved in molecular recognition between APN and S10/S120

System	Interaction residues in APN	Interaction residues in S10/S120
APN-S10	Ala248, Glu249, Gly250, Gln310, Lys317, Glu364, Thr675, Lys678, Asn679, Glu682, Arg683, Glu685, Glu724, Asn725	Phe161, Asn162, Thr164, Glu178, Tyr180, Tyr187, Ile190, Phe318, Glu320, Arg322, Tyr398, Arg401, Gln847, Tyr850, Asn851
APN-S120	Asn229, Glu230, Gln233, Ile247, Ala248, Glu249, Met253, Tyr254, Asn257, Pro261, Pro309, Lys317, His362, Ala363, Glu364, Pro365, Thr366, Glu685, Asn686	Lys162, Thr164, Asn184, Asn185, His315, Met316, Asp317, Phe318, Arg322, Leu323, Asp324, Thr350, Gly351, Arg401. Gln402, Glu854, Val856