Appendix I.
Baseline Characteristics of Patients Undergoing Either Total Hip Arthroplasty or Total Knee Arthroplasty.
| Characteristic | Hip N = 102 | Knee N = 146 | Combined N = 252 | P Value |
|---|---|---|---|---|
| Age, y (mean ± SD) | 61.5 ± 12.9 | 63.6 ± 9.4 | 62.7 ± 11.0 | 0.42 |
| Female, n (%) | 82 (78.1) | 127 (87.0) | 209 (83.3) | 0.06 |
| BMI, (mean ± SD) | 28.9 ± 6.9 | 29.5 ± 6.7 | 29.3 ± 6.8 | 0.48 |
| Duration_diag (mean ± SD) | 12.4 ± 12.1 | 15.3 ± 11.8 | 14.1 ± 12.0 | 0.02 |
| Race, n (%) | 0.59 | |||
| White | 83 (78.3) | 103 (2.9) | 186 (73.8) | |
| Black | 10 (9.4) | 17 (11.6) | 27 (10.7) | |
| Asian | 2 (1.9) | 4 (2.7) | 6 (2.4) | |
| Other | 11 (10.4) | 22 (15.1) | 33 (2.4) | |
| Smoking, n (%) | 51 (53.7) | 64 (50.0) | 115 (51.6) | 0.59 |
| Education, n (%) | 0.94 | |||
| Less than College | 13 (13.8) | 18 (14.2) | 31 (14.0) | |
| College or above | 81 (86.2) | 109 (85.8) | 190 (86.0) | |
| Employment, n (%) | 0.71 | |||
| Employed | 36 (38.3) | 48 (38.1) | 84 (38.2) | |
| Unemployed, Disabled or retire | 52 (55.3) | 73 (57.9) | 125 (56.8) | |
| Other | 6 (6.4) | 5 (4.0) | 11 (5.0) | |
| Ethnicity, n (%) | 0.87 | |||
| Hispanic or Latino | 8 (8.1) | 10 (7.5) | 18 (7.7) | |
| Not Hispanic or Latino | 90 (90.9) | 121 (90.3) | 211 (90.6) | |
| Do not wish to answer | 1 (1.0) | 3 (2.2) | 4 (1.7) | |
| Criteria, n (%) | 0.13 | |||
| Meet both criteria | 35 (38.0) | 66 (47.8) | 101 (43.9) | |
| 1987 | 15 (16.3) | 17 (12.3) | 32 (13.9) | |
| 2010 | 19 (20.7) | 35 (25.4) | 54 (23.5) | |
| Does not meet criteria | 23 (25.0) | 20 (14.5) | 43 (18.7) | |
| Medication, n (%) | ||||
| NSAIDs | 53 (52.5) | 82 (60.7) | 135 (57.2) | 0.2 |
| Steroids | 37 (35.9) | 50 (36.2) | 87 (36.1) | 0.96 |
| Methotrexate | 57 (55.3) | 60 (43.8) | 117 (48.8) | 0.08 |
| DMARD | 29 (28.2) | 41 (30.2) | 70 (29.3) | 0.74 |
| Opioids | 35 (34.3) | 53 (39.0) | 88 (37.0) | 0.46 |
| Biologic | 50 (48.5) | 78 (57.4) | 128 (53.6) | 0.18 |
| Received TXA (IV or topical), n (%) | 59 (55.7) | 105 (71.9) | 164 (65.1) | 0.01 |
| Preop hemoglobin, (mean ± SD) | 12.9 ± 1.7 | 12.6 ± 1.4 | 12.8 ± 1.5 | 0.25 |
| Platelet count (mean ± SD) | 257.6 ± 76.7 | 276.0 ± 76.9 | 268.0 ± 77.1 | 0.08 |
| Hx of previous transfusion n (%) | 2 (2.0) | 7 (5.3) | 9 (3.9) | 0.31 |
| Hx of DVT n (%) | 6 (5.9) | 5 (3.8) | 11 (4.7) | 0.54 |
| Hx of PE n (%) | 2 (2.0) | 2 (1.5) | 4 (1.7) | 1 |
| Hx of CVA n (%) | 7 (6.9) | 3 (2.3) | 10 (4.3) | 0.11 |
| Hx of Stroke n (%) | 5 (4.9) | 2 (1.5) | 7 (3.0) | 0.24 |
| Hx of Malignancy n (%) | 10 (9.8) | 11 (8.4) | 21 (9.0) | 0.71 |
| Hx of Hormone Therapy, n (%) | 10 (9.8) | 10 (7.6) | 20 (8.6) | 0.56 |
| History of Myocardial Infraction n (%) | 0 (0) | 2 (1.5) | 2 (0.9) | 0.51 |
| Estimated blood loss, mL (mean ± SD) | 180.5 ± 50.5 | 195.7 ± 75.1 | 188.8 ± 65.3 | 0.09 |
| IV TXA dose (mean ± SD) | 972.2 ± 107.4 | 995.0 ± 44.7 | 986.8 ± 74.1 | 0.1 |
| Topical TXA dose (mean ± SD) | 3000.0 ± 0.0 | 2888.9 ± 400.3 | 2928.6 ± 323.3 | 0.29 |
| Surgery Duration, min (mean ± SD) | 87.9 ± 30.9 | 95.7 ± 33.9 | 92.4 ± 32.8 | 0.03 |
| Post op transfusion needed?, Yes n (%) | 9 (8.8) | 17 (13.0) | 26 (11.2) | 0.32 |
| Indication, n (%) | ||||
| Hemoglobin < 7 | 3 (2.8) | 2 (1.4) | 5 (2.0) | 0.65 |
| Hemoglobin <8 | 1 (0.9) | 11 (7.5) | 12 (4.8) | 0.02 |
| Hypotensive | 2 (1.9) | 1 (0.7) | 3 (1.2) | 0.57 |
| Extensive surgical blood loss | 0 (0) | 2 (1.4) | 2 (0.8) | 0.51 |
| Fatigue | 1 (0.9) | 1 (0.7) | 2 (0.8) | 1 |
| MDHAQ, (mean ± SD) | 3.8 ± 1.7 | 3.8 ± 1.7 | 3.8 ± 1.7 | 0.53 |
| DAS28 – ESR, (mean ± SD) | 3.6 ± 1.3 | 3.7 ± 1.3 | 3.7 ± 1.3 | 0.43 |
| BL CDAI, (mean ± SD) | 18.3 ± 10.2 | 18.6 ± 11.4 | 18.4 ± 10.9 | 0.73 |
| ESR result (mean ± SD) | 19.6 ± 20.1 | 21.0 ± 19.4 | 20.4 ± 19.7 | 0.28 |
| CRP result (mean ± SD) | 1.6 ± 2.3 | 1.7 ± 2.7 | 1.7 ± 2.5 | 0.85 |
| CCP raw (mean ± SD) | 213.8 ± 515.5 | 155.8 ± 101.8 | 178.2 ± 329.1 | 0.98 |
| RF raw (mean ± SD) | 246.8 ± 392.4 | 439.0 ± 705.7 | 362.5 ± 605.9 | 0.23 |
| Pain score at baseline (mean ± SD) | 40.1 ± 22.8 | 40.4 ± 18.4 | 40.3 ± 20.1 | 0.77 |
| Function score at baseline (mean ± SD) | 43.4 ± 22.1 | 48.6 ± 20.0 | 46.2 ± 21.1 | 0.08 |
| Length of stay (mean ± SD) | 73.3 ± 38.2 | 87.8 ± 34.6 | 81.8 ± 36.7 | 0.0001 |
BMI, body mass index; RA, rheumatoid arthritis; TXA, Tranexamic acid; DVT, deep vein thrombosis; PE, pulmonary embolism; CVA, cerebrovascular accident; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; CDAI, Clinical Disease Activity Index; MDHAQ, Multidimensional Health Assessment Questionnaire; DAS, Disease Activity Score; DMARDs, disease modifying antirheumatic drugs; THA, total hip arthroplasty; TKA, total knee arthroplasty.