Table 2.
The relationship between women-specific reproductive factors and phenoageaccel
| reproductive factors | participants | model 1 (β) | p_value | model 2 (β) | p_value |
|---|---|---|---|---|---|
| Age at menarche | |||||
| ≤ 11 | 3121 | 0.29 (0.09, 0.50) | 0.005 | -0.08 (-0.26, 0.09) | 0.352 |
| 12 | 3778 | ref | ref | ref | ref |
| 13 | 3643 | -0.29 (-0.48, -0.09) | 0.004 | -0.08 (-0.25, 0.09) | 0.340 |
| 14 | 2046 | -0.45 (-0.68, -0.21) | < 0.001 | -0.13 (-0.34, 0.07) | 0.200 |
| ≥ 15 | 2148 | -0.19 (-0.43, 0.04) | 0.112 | 0.31 (0.10, 0.51) | 0.003 |
| P for trend | < 0.001 | 0.020 | |||
| Use of contraceptive pills | |||||
| Never | 5352 | ref | ref | ref | ref |
| Ever | 9361 | 0.14 (-0.02, 0.31) | 0.093 | -0.09 (-0.24, 0.06) | 0.233 |
| Unknown | 23 | -2.19 (-4.29, -0.09) | 0.041 | -0.92 (-2.84, 1.01) | 0.351 |
| Pregnancy history | |||||
| Never | 1765 | ref | ref | ref | ref |
| Ever | 12,522 | -0.40 (-0.64, -0.17) | 0.001 | -0.54 (-0.75, -0.34) | < 0.001 |
| Unknown | 449 | 0.17 (-0.23, 0.57) | 0.396 | 0.24 (-0.11, 0.59) | 0.182 |
| Gynecologic surgery | |||||
| Never | 5950 | ref | ref | ref | ref |
| Ever | 3919 | 0.62 (0.43, 0.81) | < 0.001 | 0.42 (0.25, 0.58) | < 0.001 |
| Unknown | 4867 | 0.25 (0.09, 0.41) | 0.003 | 0.45 (0.31, 0.60) | < 0.001 |
| Age at menopause among postmenopausal women | |||||
| < 45 | 3349 | 0.85 (0.61, 1.10) | < 0.001 | 0.54 (0.33, 0.76) | < 0.001 |
| 45–49 | 1953 | 0.56 (0.28, 0.84) | < 0.001 | 0.60 (0.36, 0.84) | < 0.001 |
| 50–54 | 2065 | ref | ref | ref | ref |
| ≥ 55 | 1271 | 0.65 (0.39, 0.91) | 0.001 | 0.68 (0.46, 0.91) | < 0.001 |
| P for trend | < 0.001 | 0.001 | |||
| Age at first delivery among parous women | |||||
| ≤ 20 | 541 | 0.53 (0.26, 0.81) | < 0.001 | 0.25 (0.12, 0.49) | 0.032 |
| 21–25 | 1599 | ref | ref | ref | ref |
| 26–30 | 1941 | 0.22 (0.08, 0.35) | 0.027 | 0.03 (-0.28, 0.33) | 0.868 |
| ≥ 31 | 1388 | 0.85 (0.41, 1.29) | < 0.001 | 0.72 (0.33, 1.10) | < 0.001 |
| P for trend | < 0.001 | < 0.001 | |||
| Age at last birth among parous women | |||||
| ≤ 20 | 541 | 0.83 (0.39, 1.27) | < 0.001 | 0.70 (0.31, 1.08) | < 0.001 |
| 21–25 | 1599 | ref | ref | ref | ref |
| 26–30 | 1941 | -0.13 (-0.42, 0.16) | 0.383 | -0.10 (-0.35, 0.16) | 0.462 |
| ≥ 31 | 1388 | 0.62 (0.32, 0.91) | < 0.001 | 0.48 (0.22, 0.74) | < 0.001 |
| P for trend | < 0.001 | < 0.001 | |||
| No. of live births | |||||
| 1–2 | 3849 | ref | ref | ref | ref |
| 3–4 | 2852 | 0.24 (-0.06, 0.54) | 0.124 | 0.03 (-0.18, 0.31) | 0.857 |
| ≥ 5 | 956 | 0.19 (-0.18, 0.55) | 0.317 | 0.07 (-0.28, 0.35) | 0.757 |
Notes model 1: Adjusted for age, ethnicity, marital status, PIR and education; model 2: BMI, smoking status, alcohol consumption, CKD, cancer, COPD, hypertension and DM were additionally adjusted
Abbreviations PhenoAgeAccel, phenotypic age acceleration