Table 3.
The relationship between women-specific reproductive factors and PhenoAgeAccel in different menopause status
| Premenopause | Postmenopause | |||||
|---|---|---|---|---|---|---|
| Participants | β | P_value | Participants | β | P_value | |
| Age at menarche | ||||||
| ≤ 11 | 1612 | -0.03 (-0.29, 0.23) | 0.815 | 1692 | -0.13 (-0.38, 0.11) | 0.284 |
| 12 | 1429 | ref | ref | 2166 | ref | ref |
| 13 | 1506 | -0.10 (-0.34, 0.15) | 0.450 | 2137 | -0.03 (-0.25, 0.20) | 0.825 |
| 14 | 790 | 0.04 (-0.27, 0.34) | 0.819 | 1256 | -0.26 (-0.53, 0.01) | 0.058 |
| ≥ 15 | 761 | 0.40 (0.09, 0.71) | 0.011 | 1387 | 0.29 (0.07, 0.47) | 0.031 |
| P for trend | < 0.001 | 0.034 | ||||
| Use of contraceptive pills | ||||||
| Never | 1686 | ref | ref | 3666 | ref | ref |
| Ever | 4410 | 0.45 (0.22, 0.69) | < 0.001 | 4951 | -0.31 (-0.51, -0.12) | 0.002 |
| Unknown | 2 | -3.51 (-8.84, 1.83) | 0.197 | 21 | -0.78 (-2.84, 1.27) | 0.454 |
| Pregnancy history | ||||||
| Never | 1253 | ref | ref | 512 | ref | ref |
| Ever | 4550 | -0.16 (-0.42, 0.11) | 0.242 | 7972 | -0.57 (-0.93, -0.22) | 0.001 |
| Unknown | 295 | 0.33 (-0.07, 0.73) | 0.106 | 154 | 0.11 (-0.57, 0.80) | 0.742 |
| Gynecologic surgery | ||||||
| Never | 3176 | ref | ref | 2774 | ref | ref |
| Ever | 25 | -0.24 (-1.72, 1.24) | 0.750 | 3894 | 0.58 (0.39, 0.77) | < 0.001 |
| Unknown | 2897 | 0.35 (0.16, 0.53) | < 0.001 | 1970 | 0.63 (0.41, 0.86) | < 0.001 |
Notes Adjusted for age, ethnicity, marital status, PIR, education, BMI, smoking status, alcohol consumption, CKD, cancer, COPD, hypertension and DM were additionally adjusted
Abbreviations PhenoAgeAccel: phenotypic age acceleration