Table 2.
Postpartum hemorrhage according to bleeding disorder and third-trimester factor level.
| Deliveries n | Severe primary PPH n (%) | Primary PPH n (%) | Estimated blood loss (mL) Median (25th-75th) |
|
|---|---|---|---|---|
| Total | 348 | 36 (10.3) | 99 (28.4) | 300 (200-500) |
| VWD type 1 | 116 | 14 (12.1) | 36 (31.0) | 350 (200-550) |
| VWD type 2 | 34 | 6 (17.6) | 17 (50.0) | 475 (300-760) |
| 2A | 16 | 4 (25.0) | 9 (56.3) | 500 (300-1050) |
| 2B | 5 | 1 (20.0) | 3 (60.0) | 500 (350-1630) |
| 2M | 10 | 1 (10.0) | 4 (40.0) | 325 (200-500) |
| 2N | 3 | 0 (0.0) | 1 (33.3) | 300 |
| VWD type 3 | 1 | 0 (0.0) | 1 (100.0) | 900 |
| Hemophilia A carrier | 167 | 13 (7.8) | 34 (20.4) | 300 (200-400) |
| Hemophilia B carrier | 30 | 3 (10.0) | 11 (36.7) | 400 (200-500) |
| Factor level in third trimester | ||||
| <50 IU/dL | 66 | 7 (10.6) | 27 (40.9) | 375 (250-600) |
| Prophylaxis | 63 | 7 (11.1) | 27 (42.9) | 400 (200-600) |
| No prophylaxis | 3 | 0 (0.0) | 0 (0.0) | 350 (300-400) |
| ≥50 IU/dL | 279 | 29 (10.4) | 71 (25.4) | 300 (200-500) |
| Prophylaxis | 28 | 4 (14.3) | 9 (32.1) | 300 (200-500) |
| No prophylaxis | 251 | 25 (10.0) | 62 (24.7) | 300 (200-500) |
| Previous cohort | 185 | 14 (8)a | 62 (34) | 300 (300-400)b |
| General population | 743.591 | 57.159 (8)a | NA | NA |
Severe primary and primary PPH were defined as ≥1000 mL and ≥500 mL of blood loss from the genital tract within 24 hours, respectively.
NA, not available; PPH, postpartum hemorrhage; VWD, von Willebrand disease.
a
In comparison with the previous cohort study by Stoof et al. [17], there was no difference in severe primary PPH incidence (8% [14/185] vs 10% [36/348]; P = .30) or primary PPH (34% [62/185] vs 28% [99/348]; P = .22).
b
Median and 95% CI.