TABLE 3.
Stratified subgroup analysis of motility parameters relative to fundoplication details.
| Intact fundoplication | Abnormal fundoplication anatomy | Nissen fundoplication | Partial fundoplication | No redo fundoplication | ≥1 redo fundoplication | |
|---|---|---|---|---|---|---|
| FLIP, n (96) | 32 (37) | 55 (63) | 75 (86) | 12 (14) | 71 (82) | 16 (18) |
| FLIP contractile response (CR), n (%) | ||||||
| Normal CR | 9 (28) | 5 (9)* | 13 (17) | 1 (8) | 13 (18) | 1 (6) |
| Borderline CR | 10 (31) | 20 (36) | 25 (33) | 5 (42) | 23 (32) | 7 (44) |
| Impaired/disordered CR | 9 (28) | 19 (35) | 26 (35) | 2 (17) | 21 (30) | 7 (44) |
| Absent CR | 3 (9) | 10 (18) | 9 (12) | 4 (33) | 12 (17) | 1 (6) |
| Spastic reactive CR | 1 (3) | 1 (2) | 2 (3) | 0 (0) | 2 (3) | 0 (0) |
| EGJ-DI, mm2/mmHg, median (IQR) | 3.0 (2.3–5.0) | 3.5 (1.9–5.3) | 3.2 (2.2–5.2) | 2.5 (1.1–5.3) | 3.1 (1.9–5.2) | 3.1 (2.6–5.2) |
| Maximum EGJ diameter, mm, median (IQR) | 17.2 (14.9–18.3) | 16.5 (13.0–18.6) | 16.5 (14.2–18.5) | 16.0 (10.8–18.8) | 16.5 (13.8–18.6) | 16.6 (13.7–18.7) |
| FLIP pressure, 60mL, mmHg, median (IQR) | 45.3 (36.2–60.1) | 36.8 (29.3–46.4)* | 39.2 (30.9–51.2) | 34.9 (25.0–50.7) | 39.4 (30.3–51.2) | 34.9 (29.6–50.5) |
| HRM (n = 63), n (%) | 25 (78) | 38 (69) | 55 (73) | 8 (67) | 51 (72) | 12 (75) |
| Primary peristalsis, n (%) | ||||||
| Normal primary peristalsis | 18 (72) | 19 (50) | 33 (60) | 4 (50) | 29 (57) | 8 (66) |
| Ineffective esophageal motility | 2 (8) | 12 (32)* | 10 (18) | 4 (50) | 10 (20) | 4 (33) |
| Absent contractility | 1 (4) | 6 (16) | 7 (13) | 0 (0) | 7 (14) | 0 (0) |
| Hypercontractile/premature | 4 (16) | 1 (3) | 5 (9) | 0 (0) | 5 (10) | 0 (0) |
| Supine IRP, mmHg median (IQR) | 15.1 (10.3–20.0) | 15.3 (10.2–20.7) | 15.2 (10.9–20.7) | 13.5 (8.0–19.9) | 15.2 (10.9–21.4) | 12.8 (7.9–16.9) |
Note:
*
p <0.05 in comparison to intact fundoplications.
Abbreviations: EGJ-DI, esophagogastric junction distensibility index; FLIP, functional lumen imaging probe; HRM, high-resolution manometry; IQR, interquartile range; IRP, integrated relaxation pressure.