Skip to main content
. 2024 Aug 14;32(8):1444–1454.e6. doi: 10.1016/j.chom.2024.07.010

Figure 2.

Figure 2

Microbial species, strain, and antibiotic resistance (AR) gene load differences between the AB+ and AB− groups of infants

(A) Heatmap of species nominally significant (p < 0.05) between the AB+ and AB− groups of infants as derived from a linear mixed model (see STAR Methods). The sample sizes at each of the time points are as follows: group AB+: W01 (n = 12), W02 (n = 11), W03 (n = 12), W04 (n = 12), W05 (n = 12), W06 (n = 12); group AB−: W01 (n = 14), W02 (n = 14), W03 (n = 15), W04 (n = 15), W05 (n = 15), W06 (n = 15).

(B) Phylogenetic trees of three species associated with AB group. Colors on the outer circle represent each individual infant. AB+ and AB− groups are depicted in the inner circles. Each tip represents a sample; samples sizes for each of the species-level genomic bins (SGBs) are as follows: Veillonella dispar (n = 67 samples from 22 infants), Bifidobacterium dentium (n = 49 samples from 13 infants), and Enterococcus faecalis (n = 54 samples from 15 infants).

(C) Total bacterial AR gene load between the two groups. x axis depicts the time point after birth in weeks (weeks 1–6). p value derived from a linear mixed-effect model without correction for other phenotypes. The sample sizes at each of the time points are as follows: group AB+: W01 (n = 12), W02 (n = 11), W03 (n = 12), W04 (n = 12), W05 (n = 12), W06 (n = 12); group AB−: W01 (n = 14), W02 (n = 14), W03 (n = 15), W04 (n = 15), W05 (n = 15), W06 (n = 15).

(D) Total AR gene load grouped by class cephalosporins. x axis depicts the time point after birth in weeks (weeks 1–6). p value derived from a linear mixed-effect model without correction for other phenotypes. The sample sizes at each of the time points are as follows: group AB+: W01 (n = 12), W02 (n = 11), W03 (n = 12), W04 (n = 12), W05 (n = 12), W06 (n = 12); group AB−: W01 (n = 14), W02 (n = 14), W03 (n = 15), W04 (n = 15), W05 (n = 15), W06 (n = 15). Boxplots visualize the median, hinges (25th and 75th percentiles), and whiskers extending up to 1.5 times the interquartile range from the hinges.