Fig. 1.

Expression patterns of DNMTs and TETs in early human embryos and hEPSC-em derived trophoblastic spheroids. A, B The gene expression patterns of DNMTs (DNMT1, DNMT3A, DNMT3B and DNMT3L) and TETs (TET1, TET2 and TET3) in TE and EPI of human preimplantation embryos from embryonic day 3 (E3) to E7 (A) and human post-implantation embryos from E7 to E14 (B). C The relative mRNA levels of DNMTs and TETs during trophoblastic spheroid differentiation from hEPSC-em at 0 h to 120 h. Data were presented as mean ± SEM, n = 3. t-test was performed. *p < 0.05