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Schematic diagram of TET2-mediated loss of DNA methylation in ENPEP promoter and gene activation during early trophoblast differentiation. Hypermethylated ENPEP in morula-like hEPSC-em is demethylated through TET2 recruitment on ENPEP promoter during trophoblastic spheroid differentiation and TSC derivation. Deletion of ENPEP or TET2 in hEPSC-em compromises trophoblast differentiation potency and reduces adhesion and invasion of derived trophoblastic spheroids
