Table 2:
All presently known human γδ TCR ligands.
| Known Ligands | γδ TCR | Known Presentation | Ref. | Structure |
|---|---|---|---|---|
| MHC/MHC-like | ||||
| HLA:peptide | Vδ1+ | Peripheral blood | (45, 87) | 5F3 TCR-HLA-A*02-MART1 |
| MICA | Vδ1+ | Peripheral blood | (74) | N/A |
| CD1a | Vδ1+ | Peripheral blood | (28) | CO3 TCR-CD1a-sulfatide |
| CD1b | Vδ1+ | Peripheral blood | (70) | N/A |
| CD1d | Vδ1+/Vδ3+ | Peripheral blood | (25, 27) | 9C2 TCR-CD1d-αGalCer DP10 TCR-CD1d-sulfatide |
| CD1c | Vδ1+ | Peripheral blood | (67) | N/A |
| MR1 | Vδ1+/Vδ3+ | Peripheral blood | (46, 47) | G7 TCR-MR1–5-OP-RU G83.C4 TCR-MR1–5-OP-RU |
| Butyrophilins | ||||
| BTN2A1/BTN3A1 | Vγ9Vδ2+ | Peripheral blood | (4, 20–23). | G115 TCR-BTN2A1 |
| BTNL3/BTNL8 | Vγ4+ | Enteric organs | (42) | N/A |
| Other | ||||
| Phycoerythrin (PE) | Vδ1+ | Unknown | (15) | N/A |
| EphA2 | Vγ9Vδ1+ | Peripheral blood | (75) | N/A |
| hMSH2 | Vδ2+ | Peripheral blood | (88) | N/A |
| histidyl tRNA synthetase | Vγ3Vδ2+ | Peripheral blood | (18) | N/A |
| Annexin A2 | Vδ3+ | Unknown | (11) | N/A |
| EPCR | Vγ4Vδ5+ | Peripheral blood | (24) | N/A |