Structured Graphical Abstract.

The overview figure presents the P-values associated with the interaction terms on each endpoint per subgroup. Green corresponds to an overall significant effect in the main trial, and for the predefined subgroups to no statistically significant interaction term on the associated clinical endpoint. The HFH/CV death endpoint refers to a time to event analysis of the composite endpoint HFH or CV death. AF, atrial fibrillation; CV, cardiovascular; DM, diabetes mellitus; EF, ejection fraction; GDMT, guideline-directed medical therapy; ICD, implantable cardiac defibrillator; CRT, cardiac resynchronization therapy; HF, heart failure; HFH, heart failure hospitalization; PA, pulmonary artery; PAP, pulmonary artery pressure.