FIGURE 1.

OA cell lines used are resistant to different chemotherapies. (A–D) Calculation of IC₅₀ values using the MTT assay upon treatment with cisplatin (A), paclitaxel (B), doxorubicin (C), or vincristine (D) for 72 h. IGROV1 survival percentages are represented by black dots connected by a black line, IGROV1CDDP is represented in red, and IGROV1VCR is represented in blue. All experiments have been performed on three to six independent biological replicates. For each point, the mean ± SEM is represented. (E) IC₅₀ values obtained in the different models and with the indicated conditions. The table shows the values obtained in IGROV1, IGROV1CDDP, and IGROV1VCR with cisplatin, paclitaxel, doxorubicin, or vincristine.