FIGURE 3.

PEP-010 combination with paclitaxel shows a beneficial effect on OA cell lines resistant to chemotherapies. (A, B) IC₅₀ values obtained by calculation using the MTT assay upon treatment of IGROV1VCR with the indicated drugs for 72 h. The IC₅₀ value decreases when PEP-010 is added to paclitaxel. Four independent biological replicates have been analyzed. (C) The combination effect was also analyzed by Annexin V/PI staining in IGROV1VCR treated with increasing doses of paclitaxel in monotherapy or with the addition of PEP-010 (25 µM) for 72 h. Three independent biological replicates have been analyzed. *, <0.05; **, 0.001 < p < 0.05; and ***, p < 0.001.