Fig. 3.

Nine of ten strong fmo-2 inducers increase lifespan in C. elegans. Survival curves of wild-type C. elegans after drug treatments. Lifespans were significantly (P < 0.05 by log-rank) extended by the indicated fmo-2 inducers under the specified concentration. Wild-type C. elegans (N2 Bristol) were synchronized to L4 stages, treated with indicated drugs, and then lifespan was measured. ****indicates P < 0.0001; ***indicates P < 0.001; **indicates P < 0.01 when compared to control treated worms (log-rank test). P-values (log-rank test), lifespan replicates, and lifespan statistics are listed in Supplementary Table 3. Each lifespan was performed at least two times with multiple doses. The best dose was performed at least four times, with one replicate shown here