Table 2.
Summary of relevant research on traditional Chinese medicine treatment for psoriasis.
| Author | Subject of Study | n1/n2 (E/C) | Experimental group intervention | Control group intervention and doses | Period of treatment | Outcome measure |
Gut Microbiota Change | Other Outcome |
|---|---|---|---|---|---|---|---|---|
| Liet al., 2021 (Li et al., 2021) | Specific pathogen-free BALB/c male mice (7 weeks old, 16–18 g) | 8/8 | sodium abietate (40 mg/kg/d) | Imiquimod cream (5%) (62.5 mg/d) | 7days | 16S rRNA sequencing analyses(V3-V4 hypervariable region) | ↑Bacteroidetes ↓Firmicutes, Tenericutes phylum ↑Bacilli class ↑Bacillales order ↑Porphyromonadaceae Prevotellaceae, Planococcaceae Enterobacteriaceae family ↓Anaerotruncus Christensenella genus ↑Kurthia, Citrobacter, and Klebsiella genus |
↓the ratio of Th17 cells ↑Treg cell (CD4+/CD25+/Foxp3+) rate ↓IL-17A, IL-23, TNF-α, and IL-1β |
| Cai Z et al., 2023 (Cai et al., 2023) | BALB/c mice(8–10 weeks, 20–22 g) | 4/4 | curcumin (100 mg/kg/day) | imiquimod cream (62.5 mg/d) | 6days | 16S rRNA sequencing analyses(V3-V4 hypervariable region) | ↑flora diversity ↑Mucispirillum, unclassified_desulfovibrionaceae genus ↑Deferribacters, Desulfovibrionia class ↑clostridia, Deferribacteresw, and Desulfovibrionia class ↑Alistipes, Desulfovibrio, Mucispirillum, and Rikenella genus |
↑IL-6, IL-17A, IL-22, IL-23, TNF-α, TGF-β1, IL-10 |
| Di T et al., 2021 (Di et al., 2021) | Babl/c male mice, aged 6–8 weeks, | 8/8 | Tuhuaiyin15 g/Kg intragastric administration | Imiquimod cream (5%) (62.5 mg/d) | 7days | 16S rRNA sequencing analyses | ↑The diversity of intestinal microbiota ↑ ovatus, RF32, Christensenellaceae,Clostridium |
↓IL-17A, IL-22, GRO ↑MCP-1, MIP-1 β |
| Huang Gang et al., 2023 (Huang Gang. et al., 2023) | BALB/c male mice (6–8 weeks, 20–22 g) | 6/6 | rhinoceros horn and rehmannia decoction 320mg/mL/d | Imiquimod cream (5%) (42 mg/d) | 14days | Fecal bacterial culture | ↑Lactobacillus, Bifidobacterium ↓Enterococcus, Escherichia coli |
↓IL-17, IL-23,TNF-α |
| Huang Gang et al., 2022 (Huang et al., 2022) | Blood heat psoriasis | 30/30 | rhinoceros horn and rehmannia decoction 200ml,twice/d+Jinhuang Ointment | Acitretin Capsules 20mg/d+Jinhuang Ointment | 8weeks | Fecal bacterial culture | ↑Lactobacillus, Bifidobacterium ↓Enterococcus |
↓Th17,Treg/Th17 ↑Treg |
| ZHANG Yuting et al., 2024 (Zhang et al., 2024) | Spleen dampness syndrome of psoriasis vulgaris | 20/20 | Spleen detoxification soup 250ml,twice/d+Calcipotriol Ointment | Healthy control | 4weeks | 16S rRNA sequencing analyses | ↑Gammaproteobacteria,Actinobacteria, ↓Bacteroidota-Baacteroidia phylum ↑Enterobacteriaceae,Bifidobacteriacease family ↑Bifidobacterium Escherichia-Shigella ↓Bacteroides |
|
| LUO Saijun.2022 (Luo, 2022) | BALB/c male mice (6 weeks, 20 g) | 6/6 | Zhuhuang granules250mg/ml | Imiquimod cream (5%) (42 mg/d) | 7days | 16S rRNA sequencing analyses | ↑Alistipes,Lactobacillus,Muribaculaceae S24-7 | ↓IL-1β,IL-6,TNF-α |
| HU Hui-ying et al., 2020 (Hu et al., 2020) | Male SD mice | 8/8 | Runzao Zhiyang capsule(RZC)/d | 5%Propranolol | 2weeks | Fecal bacterial culture | ↓Enterococcus, Escherichia coli ↑Lactobacillus. Bifidobacterium. |
↓IL-6,TNF-α,IL-17 ↑IL-10 |
↓, decreased; ↑, increased; rRNA, ribosomal ribonucleic acid.