Table 2.

Univariate and multivariate analysis of factors associated with survival and recurrence of CRC patients.

	OS								DFS
	Univariate analysis				Multivariate analysis				Univariate analysis				Multivariate analysis
	HR	HR 95% CI		p	HR	HR 95% CI		p	HR	HR 95% CI		p	HR	HR 95% CI		p
		Low	High			Low	High			Low	High			Low	High
Sex	0.929	0.581	1.486	0.760					0.663	0.423	1.037	0.072
Age	1.141	0.710	1.832	0.586					1.031	0.658	1.616	0.893
Histologic grade	1.989	1.249	3.165	0.004	0.498	0.498	0.498	0.498	1.553	0.991	2.435	0.055
Primary tumorsize	0.789	0.557	1.119	0.184					0.746	0.536	1.037	0.082
TMN stage (T)	3.228	2.024	5.147	0.000	3.184	1.477	6.860	0.003	2.331	1.507	3.607	0.000	2.178	1.166	4.068	0.015
TMN stage (N)	2.531	1.903	3.367	0.000	1.667	0.816	3.405	0.161	2.111	1.590	2.803	0.000	1.611	0.817	3.178	0.169
TMN stage (M)	12.429	7.444	20.753	0.000	4.053	1.545	10.632	0.004	5.141	2.853	9.264	0.000	1.448	0.573	3.659	0.433
Dukes stage	5.628	3.348	9.462	0.000	1.040	0.322	3.358	0.948	3.622	2.289	5.732	0.000	0.837	0.277	2.530	0.753
Vascular invasion	2.955	1.667	5.239	0.000	1.448	0.598	3.509	0.412	2.185	1.203	3.969	0.010	1.334	0.610	2.917	0.471
Nerve invasion	2.580	1.527	4.359	0.000	1.068	0.457	2.497	0.879	1.346	0.753	2.407	0.316
General type	2.173	1.257	3.758	0.005	1.427	0.552	3.691	0.463	1.890	1.131	3.159	0.015	1.584	0.722	3.479	0.251
CEA level	2.606	1.489	4.561	0.001	1.380	0.648	2.939	0.404	1.987	1.195	3.303	0.008	1.122	0.599	2.102	0.719
CA125 level	2.066	1.029	4.149	0.041	0.858	0.344	2.140	0.742	1.550	0.760	3.164	0.228
CA199 level	3.498	1.994	6.137	0.000	1.684	0.752	3.770	0.205	3.349	1.982	5.659	0.000	2.054	1.085	3.888	0.027
History of intestinal polyps	0.741	0.269	2.037	0.561					0.638	0.233	1.749	0.383
Chemotherapy	3.129	1.698	5.768	0.000	1.725	0.748	3.976	0.201	3.532	1.964	6.353	0.000	2.851	1.344	6.048	0.006
HOIP expression	2.632	1.413	4.902	0.002	2.604	1.030	6.581	0.043	1.476	0.894	2.438	0.128