Figure 4.

CellChat cell–cell communication networks inferred from expression of ligand-receptor pairs. Circle plot showcasing the (A) differential number of ligand-receptor interactions and (B) differential communication probability between OVT73 and controls for any two cell types. Red arrows indicate increased number/communication probability in OVT73, blue arrows indicate decreased number/communication probability in OVT73. Thickness of line indicates greater number/communication probability. The total number of ligand-receptor interactions and total interaction strength for OVT73 and controls is also shown as bar graphs on the top right. (C) Differential information flow between OVT73 and control cell types for outgoing (ligand to receptor) and incoming (receptor to ligand) signalling pathways. The information flow for a given signalling pathway is defined as the sum of communication probabilities of all ligand receptor pairs in the pathway. A positive value indicates more communication in OVT73.