Figure 6.

Gene regulatory networks show reduced CREB regulon activity in OVT73. (A) CREB-related transcription factor regulated gene modules (regulons) network. The associated transcription factor regulon is shown as triangles with gene members of the regulon connected as dots. The two panels on the right show the log2 fold change of differentially expressed gene members of the regulon between OVT73 and controls in D1 MSNs and D2 MSNs. (B) Differential regulon activity was computed by subtraction of regulon activity between OVT73 and controls. A randomised permutation test with 2000 permutations was performed to determine significant differential regulon activity between OVT73 and control cell types. P-values of the randomised permutation test are shown in the parentheses.