Table 2.

Marginal means of NMR-based metabolic biomarkers in osteoporosis patients with and without incident fracture, divided by gender.

	Male			Female
	Osteoporosis without fracture N = 840	Osteoporosis with fracture N = 138	p value	Osteoporosis without fracture N = 4188	Osteoporosis with fracture N = 327	p value
Free Cholesterol in HDL	0.25 (0.22, 0.30)	0.25 (0.23, 0.30)	0.576	0.32 (0.27, 0.37)	0.32 (0.28, 0.38)	0.149
Total Lipids in HDL	2.69 (2.36, 3.12)	2.67 (2.41, 3.12)	0.510	3.23 (2.83, 3.66)	3.22 (2.86, 3.81)	0.199
Total Cholines	2.34 (2.06, 2.60)	2.38 (2.15, 2.65)	0.185	2.68 (2.43, 2.93)	2.69 (2.44, 2.98)	0.469
Sphingomyelins	0.41 (0.36, 0.45)	0.41(0.37, 0.46)	0.238	0.47 (0.42, 0.52)	0.47 (0.43, 0.52)	0.270
Degree of Unsaturation	1.33 (1.28, 1.39)	1.32 (1.27, 1.37)	0.118	1.39 (1.34, 1.44)	1.38 (1.33, 1.43)	0.280
Polyunsaturated Fatty Acids to Total Fatty Acids percentage	42.27 (38.86, 44.64)	41.32 (38.19, 44.05)	0.142	43.59 (41.17, 45.55)	43.29 (41.07, 45.23)	0.138
Histidine	0.06 (0.06, 0.07)	0.06 (0.06, 0.07)	0.400	0.06 (0.06, 0.07)	0.06 (0.06, 0.07)	0.114
3-Hydroxybutyrate	0.04 (0.03, 0.07)	0.05 (0.03, 0.08)	0.598	0.04 (0.03, 0.08)	0.05 (0.03, 0.09)	0.001
Acetone	0.01 (0.01, 0.02)	0.01 (0.01, 0.02)	0.408	0.01 (0.01, 0.02)	0.01 (0.01, 0.02)	0.003
Total Lipids in Medium HDL	0.93 (0.81, 1.08)	0.94 (0.82, 1.08)	0.352	1.10 (0.96, 1.24)	1.10 (0.97, 1.27)	0.268
Phospholipids in Medium HDL	0.44 (0.39, 0.51)	0.45 (0.40, 0.51)	0.293	0.51 (0.45, 0.58)	0.51 (0.458, 0.60)	0.273
Cholesteryl Esters in Large HDL	0.17 (0.11, 0.26)	0.16 (0.12, 0.24)	0.844	0.27 (0.19, 0.38)	0.28 (0.18, 0.39)	0.273
Triglycerides in Small LDL	0.01 (0.01, 0.02)	0.01 (0.01, 0.02)	0.470	0.01 (0.01, 0.02)	0.01 (0.01, 0.02)	0.558
Phospholipids in Very Large HDL	0.06 (0.04, 0.09)	0.06 (0.05, 0.08)	0.604	0.09 (0.07, 0.13)	0.09 (0.07, 0.13)	0.476
Concentration of Large HDL Particles	0.00 (0.00, 0.00)	0.00 (0.00, 0.00)	0.970	0.00 (0.00, 0.00)	0.00 (0.00, 0.00)	0.248