Table 6.

Safety evaluation of study subjects before (0 W) and after (12 W) NMN intervention

	Unit		Placebo group			NMN group			ANCOVA
Systolic blood pressure	mmHg	0 W	124	±	19	124	±	12
		12 W	124	±	19	122	±	15	0.494
Diastolic blood pressure	mmHg	0 W	77	±	13	75	±	10
		12 W	77	±	13	74	±	11	0.557
Pulse rate	bpm	0 W	71	±	9	69	±	10
		12 W	73	±	9	69	±	9	0.157
White blood cells	/μL	0 W	5356.2	±	1084.1	5339.3	±	1571.8
		12 W	5166.9	±	1257.3	5086.7	±	1819.7	0.749
Red blood cells	× 104/μL	0 W	446.6	±	33.5	458.5	±	37.1
		12 W	441.4	±	37.6	451.4	±	41.2	0.631
Hemoglobin	g/L	0 W	137.5	±	11.1	140.1	±	10.6
		12 W	137.1	±	12.2	140.0	±	11.6	0.470
Hematocrit	%	0 W	0.43	±	0.03	0.44	±	0.03
		12 W	0.42	±	0.03	0.42	±	0.03	0.582
Platelets	× 104/μL	0 W	24.5	±	5.0	25.0	±	4.6
		12 W	24.2	±	4.8	25.0	±	4.3	0.568
Total protein	g/L	0 W	70.41	±	2.44	71.73	±	3.49
		12 W	70.86	±	2.76	72.27	±	3.60	0.521
Albumin	g/L	0 W	43.17	±	2.80	43.77	±	2.25
		12 W	42.90	±	2.76	43.73	±	2.03	0.333
Total bilirubin	mg/dL	0 W	0.79	±	0.26	0.73	±	0.22
		12 W	0.79	±	0.31	0.77	±	0.25	0.477
Alkaline phosphatase	IU/L	0 W	73.4	±	18.0	64.1	±	19.7
		12 W	73.3	±	17.0	63.2	±	18.8	0.214
Lactate dehydrogenase	IU/L	0 W	178.9	±	20.5	180.5	±	30.4
		12 W	170.2	±	15.8	175.5	±	28.3	0.999
Aspartate aminotransferase	IU/L	0 W	22.2	±	3.7	23.7	±	4.8
		12 W	22.1	±	5.0	23.3	±	5.1	0.858
Alanine aminotransferase	IU/L	0 W	16.9	±	4.4	19.7	±	7.2
		12 W	16.4	±	5.3	18.4	±	5.6	0.771
Gamma-glutamyl transpeptidase	IU/L	0 W	30.6	±	20.1	23.8	±	13.3
		12 W	29.9	±	20.6	23.9	±	17.2	0.908
Creatine kinase	IU/L	0 W	158.1	±	181.5	113.9	±	58.8
		12 W	114.6	±	51.7	111.1	±	56.9	0.233
Total cholesterol	mmol/L	0 W	5.79	±	0.93	5.56	±	0.88
		12 W	5.69	±	0.88	5.66	±	1.00	0.194
Triglycerides	mmol/L	0 W	1.08	±	0.61	0.94	±	0.47
		12 W	1.26	±	0.74	1.04	±	0.55	0.390
HDL cholesterol	mmol/L	0 W	1.77	±	0.51	1.76	±	0.38
		12 W	1.68	±	0.52	1.72	±	0.38	0.194
LDL cholesterol	mmol/L	0 W	3.34	±	0.65	3.15	±	0.72
		12 W	3.19	±	0.71	3.21	±	0.76	0.146
Urea nitrogen	mmol/L	0 W	5.60	±	1.44	6.04	±	1.28
		12 W	5.38	±	1.00	5.69	±	1.13	0.650
Creatinine	μmol/L	0 W	73.55	±	13.91	72.28	±	14.65
		12 W	67.58	±	14.32	67.66	±	14.96	0.354
Uric acid	μmol/L	0 W	340.9	±	73.0	320.4	±	75.2
		12 W	343.3	±	83.6	326.0	±	82.5	0.797
Sodium	mmol/L	0 W	140.8	±	1.6	142.0	±	1.5
		12 W	139.2	±	1.7	139.5	±	1.6	0.897
Potassium	mmol/L	0 W	4.38	±	0.35	4.52	±	0.27
		12 W	4.36	±	0.25	4.50	±	0.36	0.219
Chloride	mmol/L	0 W	104.4	±	1.7	104.5	±	2.2
		12 W	103.9	±	1.8	103.4	±	2.1	0.204
Calcium	mmol/L	0 W	2.30	±	0.07	2.35	±	0.06
		12 W	2.33	±	0.07	2.37	±	0.09	0.545
Glucose	mmol/L	0 W	5.28	±	0.47	5.45	±	0.46
		12 W	5.19	±	0.36	5.35	±	0.40	0.443
HbA1c(NGSP)	%	0 W	5.49	±	0.31	5.45	±	0.26
		12 W	5.47	±	0.30	5.46	±	0.27	0.616

Means ± standard deviation are shown

Safety analysis population: N = 59 (placebo group N = 29, NMN group N = 30)