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. 2024 Aug 20;14:19341. doi: 10.1038/s41598-024-70294-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Soluble Guanylyl Cyclase activation provides neuroprotection against vincristine-induced neurotoxicity. (A and B) Levels of cGMP in ES-MNs (A) and DRG neurons (B) shown as a proxy of sGC activation. Data are presented as mean ± SEM of 3 independent experiments (one-way ANOVA for A: **p = 0.0077, ****p < 0.0001 relative to DMSO treated cells. One-way ANOVA for B: DMSO vs VCR *p = 0.0468, DMSO vs SIN-1 **p = 0.0011, DMSO vs VCR + SIN-1 *p = 0.0363,). (C and D) Effect of ODQ treatment on SIN-1 neuroprotective activity in ES-MNs (C) and DRG neurons (D). Values are means ± SEM of 4 biological replicates (one-way ANOVA: ***p = 0.0002, ****p < 0.0001 relative to DMSO treated cells). (E and F) sGC activators SIN-1 and BAY 41–2272 protect neurite length against VCR in ES-MNs (E) and DRG neurons (F). Doses of compounds are expressed in a log scale. Values are means of six technical replicates; error bars are not shown for clarity. See also Figure S3.