Table 05.
ADME analysis of the four bioactive compounds from Bryophyllum pinnatum.
| Compounds | Absorption |
Distribution |
Metabolism |
Excretion |
|||
|---|---|---|---|---|---|---|---|
| C2P | HIA (%) | P-gpI | BBB |
CNS |
CYP1A2 | TC | |
| (Permeability) | |||||||
| Bryophyllin A | 1.351 | 85.237 | No | −0.635 | −3.077 | No | 0.254 |
| Bryophyllin B | 0.57 | 92.164 | No | −0.973 | −3.271 | No | 0.375 |
| Bryotoxin A | 0.616 | 56.276 | Yes | −1.318 | −3.32 | No | 0.373 |
| Bryotoxin B | 1.116 | 100 | No | −0.896 | −3.356 | No | 0.343 |
Here, TC = total clearance and measured in log mL/min/kg; I = inhibitor; Caco-2 permeability (C2P) (log Papp in 10−6 cm/s); human intestinal absorption (HIA) (% absorbed), and P-glycoprotein inhibitor (P-gpI); The blood-brain barrier (BBB) (log BB) and central nervous system (CNS) permeability (log PS).