Table 5. Factors associated with parathyroidectomy among those with PHPT using a complete case analysis (n=373).
| Covariate | Odds ratio (95% CI) | P value |
|---|---|---|
| Age | 0.55 | |
| <30 years | Reference | |
| 30–39 years | 0.31 (0.03–3.6) | 0.35 |
| 40–49 years | 0.11 (0.01–0.99) | 0.048 |
| 50–59 years | 0.20 (0.03–1.5) | 0.12 |
| 60–69 years | 0.14 (0.02–1.1) | 0.06 |
| 70–79 years | 0.17 (0.02–1.4) | 0.11 |
| ≥80 years | 0.15 (0.02–1.3) | 0.09 |
| Race | 0.06 | |
| White | Reference | |
| Black | 0.38 (0.15–0.99) | 0.049 |
| Other | 1.5 (0.45–4.8) | 0.52 |
| Unknown/declined | 0.20 (0.03–1.2) | 0.08 |
| Insurance status | 0.66 | |
| Private | Reference | |
| Medicare | 0.67 (0.32–1.4) | 0.29 |
| Medicaid | 0.69 (0.24–2.0) | 0.50 |
| Other/uninsured/unknown | 0.65 (0.25–1.7) | 0.37 |
| Charlson comorbidity index | 0.13 | |
| 0 | Reference | |
| 1 | 1.3 (0.65–2.6) | 0.46 |
| 2+ | 0.56 (0.26–1.2) | 0.15 |
| Laboratory values | ||
| Calcium | 0.13 | |
| <11.0 mg/dL | Reference | |
| 11.1–11.5 mg/dL | 0.70 (0.37–1.3) | 0.28 |
| 11.6–12.0 mg/dL | 1.8 (0.74–4.3) | 0.20 |
| >12.0 mg/dL | 0.69 (0.12–2.4) | 0.57 |
| PTH | 1.01 (0.999–1.01) | 0.08 |
| Creatinine | 1.15 (0.36–3.7) | 0.81 |
| 25-OH vitamin D | 1.02 (1.01–1.04) | 0.008 |
| Indications for surgery | ||
| Kidney stones | 1.3 (0.59–2.9) | 0.50 |
| Osteoporosis | 1.6 (0.84–3.1) | 0.15 |
| Bone fracture | 0.25 (0.06–1.1) | 0.058 |
| eGFR <60 mL/min/1.73 m2 | 1.3 (0.57–2.7) | 0.58 |
| 24-hour urine calcium >250 (women)/>300 (men) mg/24 hours | 3.9 (2.1–7.4) | <0.001 |
| Endocrinology evaluation | 0.69 (0.38–1.3) | 0.23 |
| Surgical evaluation | 8.1 (4.5–14.6) | <0.001 |
PHPT, primary hyperparathyroidism; CI, confidence interval; PTH, parathyroid hormone; eGFR, estimated glomerular filtration rate.