Table 1.

The primary mechanisms through which natural phages and enzymes derived from them serve as the foundation for eliminating bacteria in both planktonic and biofilm forms involve.

The mode of action of natural phage and their enzymes
Planktonic and antibiotic-resistant bacteria	Antibiotic-resistant biofilms
•Disrupted pili	•Destroying the extracellular matrix
•Disrupted flagella	•Preventing quorum sensing
•Disrupted peptidoglycan	•Increasing the permeability of antibiotics into the inner layers of the biofilm
•Disrupted CRISPR
•Disrupted metabolic pathways
•Disrupted secretion systems
•Disrupted chromosomes
•Disrupted RNA
•Disrupted RNA polymerase
•Disrupted ribosomes