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. 2024 Aug 3;10(15):e35592. doi: 10.1016/j.heliyon.2024.e35592

Table 6.

Fractional inhibitory concentration (FIC) Index of ciprofloxacin in combination with bioactive extracts of Posidonia oceanica against Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212. MR1-viscous part from the methanolic crude extract of rhizome. MR2-granulated part from the methanolic crude extract of rhizome. ER-ethanolic extract of the rhizome. A-additive. I-indifference. S-synergy.

Species/Samples Optimal Combination
FIC Index
Ciprofloxacin (mg/L) ER (mg/mL) <0.5 >0.5
S. aureus 0.001 0.64 1.0 (I)
E. faecalis 0.002 0.16 0.5 (A)
Ciprofloxacin (mg/L) MR1(mg/mL) < 0.5 > 0.5
S. aureus 0.001 1.28 1.0 (I)
E. faecalis 0.25 0.08 0.4 (S)
Ciprofloxacin (mg/L) MR2(mg/mL) < 0.5 > 0.5
S. aureus 0.001 1.28 1.0 (I)
E. faecalis 0.25 0.08 0.4 (S)