Fig. 2.

12-months-old transgenic Tau-VLW mice are characterized by brain glucose hypometabolism. (A) Representative images depicting brain [¹⁸F]FDG uptake in Tau-VLW (white bars) vs age-matched WT mice (striped bars). (B) [¹⁸F]FDG-PET neuroimaging quantification is shown as SUV in the cortex and in the hippocampus. Data are presented as mean ± SEM (n = 7/group). Unpaired Student's t-test was used to analyse significant differences. **p < 0.01, ***p < 0.001.