Fig. 3.

Evaluation of peripheral markers of glucose metabolism in 12-months-old wild type and Tau-VLW mice. (A) Intraperitoneal glucose tolerance test (IpGTT) on overnight fasted mice and (B) Area under the curves. Blood glucose concentrations under basal conditions (time 0, before 2 g/kg BW glucose overload) as well as 15, 30, 60, 90, 120 and 150 min later are shown. Values are expressed as means ± SEM (WT, n = 8; Tau, n = 10). Significant differences between WT and Tau within time are depicted as *p < 0.05, **p < 0.01. The trend to significance #p = 0.08 is also shown (two-way ANOVA followed by post-hoc Bonferroni correction). Significant differences when compared with time 0 within WT (^ap<0.001, ^bp < 0.01, the trend to significance ^cp = 0.06 is also shown) and, within Tau (^dp < 0.001, ^ep < 0.01) (one-way ANOVA followed by Dunnett's correction for comparisons with time 0). ^&p < 0.0001, when compared area under the curves (C) Fasting plasma insulin concentrations and (D) HOMA-IR index. (WT, n = 9; Tau, n = 3). (E) Body weight. (WT, n = 8; Tau, n = 10). All values are expressed as means ± SEM. Unpaired Student's t-test was used to analyse significant differences. *p < 0.05, when comparing WT with Tau mice.