Fig. 4.

Effect of chronic metformin treatment on brain glucose metabolism in Tau-VLW transgenic mice. (A) Coronal, transaxial and sagittal views of the mouse MRI brain template with the regions of interests (ROIs) corresponding to the main brain areas. (B) Representative [¹⁸F]FDG-PET images in SUV scale (coronal, transaxial and sagittal planes) of TC (left panel) and TM (right panel) from 9- to 18 months-old. (C) [¹⁸F]FDG-PET SUV changes in cortex, hippocampus and whole brain. Data are shown as mean ± SEM (TC, n = 12, 12, 10 and 7 at 9, 11, 15 and 18-months-old mice, respectively; TM, n = 13, 12, 11 and 11 at 9, 11, 15 and 18-months-old mice, respectively). *p < 0.05 compared to TC; ^#p < 0.05 comparing TM at 18 months vs 15 months, Wilcoxon signed-rank test.